The imperative of high-purity extraction, active component ratio verification, and global phytopharmaceutical regulatory alignment.
Reducing allergenic ginkgolic acids below the threshold of 5 ppm (USP/EP) and even 1 ppm for specialty pharmacological specifications. Advanced separation ensures maximum bioactivity and safety.
Maintaining the gold-standard molecular ratio of 24% Ginkgo Flavone Glycosides and 6% Terpene Lactones (including Ginkgolides A, B, C, and Bilobalide) for standardized cognitive and microcirculatory benefits.
Navigating global regulatory landscapes including EP 10.0, USP 43, ChP 2020, and specific local customs requirements. Direct validation processes for dynamic import compliance certificates (CEP/DMF).
UniCare is a professional supplier of natural active ingredients. Our products are widely used in various fields such as dietary supplement, food, cosmetics and pharmaceuticals. We focus on product development and quality stability, and insist on growing together with our customers around the world.
UniCare has deep cooperation with several excellent Chinese manufacturers who have complete quality management system certifications, including but not limited to GMP, EUGMP, CEP, ISO9001, ISO22000, and HACCP. Each factory has independent testing capabilities and is equipped with advanced and efficient testing equipment to ensure the high quality and long-term stability of each batch of products.
Guided by innovation, technology, and community dedication to deliver global botanical ingredient excellence.
Continuously seeking unexplored synergistic properties within target botanicals to create standardized solutions that meet current pharmacological and cosmetic needs.
Optimizing plant breeding, yield density, extraction parameters, and molecular purity indexes to maintain sustainable production efficiencies year-on-year.
Deploying automated, industrial-scale closed extraction loops to preserve active matrices while safely and efficiently removing unwanted residual fractions.
Fostering cooperative farming paradigms, supporting rural regeneration at wild crop collection zones, and maintaining fair, sustainable operational safety standards.
UniCare attaches great importance to the hardware conditions of production equipment and has the largest and most advanced extraction factory in China. The entire production line in UniCare is controlled by a modern, intelligent, automatic control system. Until now, UniCare has built up two GMP workshops, containing six multi-functional extraction lines, among which there is the only production line for Ginkgo Biloba Extract of acetone process in the whole China. Here are several other production lines including fermentation production lines and Chinese medicine pieces. A total of 30,000 tons of various Chinese medicine plant raw materials can be processed each year.
The factory has passed the China GMP certification, adhering strictly to global quality guidelines.
The EU-GMP and CEP certifications of Ginkgo Biloba Extract ensure seamless European pharmaceutical integration.
All extraction production lines adopt modern, intelligent, and automated control systems to guarantee batch stability.
We own the most advanced industrial extraction equipment currently in operation across China.
High throughput capability of raw herbal materials ensures secure raw material processing pathways.
Includes three annular dynamic countercurrent lines (10T & 15T), two multi-functional lines (32x 6m³ tanks), and one round dynamic countercurrent line (10T).
We operate China's only acetone-based extraction line for Ginkgo Biloba Extract that meets stringent EU GMP standards.
Equipped with six 20-ton capacity fermentation tanks dedicated to the production of premium enzyme-modified products.
Ensuring trace-level control, safety limits, and regulatory documentation across every shipment.
United New Life has established a leading and complete quality control system, and strictly controls the high quality of products in accordance with the quality system.
With advanced testing instruments, strict control of product quality, to provide every customer with high quality products. Detectable items are: Signature component detection (HPLC or UV), solvent residues GC, pesticide residues (organochlorine detection) GC-MS-MS, heavy metals (lead, arsenic, mercury, cadmium, copper) ICP-MS microscopic identification, moisture, dry weight loss, ash, microbial limits, thin layer identification, weighing, conductivity, PH, sulfur dioxide residue, routine detection, etc.
Important testing instruments are: Two UHPLC Agilent 1290 ultra-high performance liquid chromatographs, four HPLC Agilent 1260 high performance liquid chromatography sets, there are two HPLC Shimadzu LC-20AT high performance liquid chromatographs, two HPLC Dionex (Diane) CU3000, two Shimadzu evaporative light scattering detector (ELSD) 2000ES, one Shimadzu GC2010 gas chromatograph, and one Shimadzu AA-7000 atomic absorption system.
Our Central Lab is qualified by CNAS, operating under strict GMP regulations. The facility features highly specialized analytical departments that coordinate sample isolation, quantitative analysis, stability studies, and long-term shelf-life tracking.
UHPLC Agilent 1290 (×2)
HPLC Agilent 1260 (×4)
HPLC Shimadzu LC-20AT (×2)
ELSD Shimadzu 2000ES (×2)
Shimadzu GC-2010 (×1)
Shimadzu AA-700 (×1)
| Quality Control Items | Analysis Details & Methods |
|---|---|
| Active Ingredient Analysis | Assay, identification via HPLC / UV |
| Hazardous Substance Analysis | Heavy metals (ICP-MS), pesticide residue (GC-MS-MS), solvent residue (GC) |
| Microbe Analysis | Bacterium, Escherichia coli, Yeast & mould, specific microbial tests |
| Raw Material Control | Pesticide residue, allergen origin, Non-GMO verification, botanical origin tracking |
| Laws & Regulations | Continuous investigation and alignment with regulations of China, US (FDA), and EU (EMA) |
| Stability Test | Guarantee the shelf life according to stability study and stress testing |
| Others | pH value, moisture, ash, optical rotation, particle size, bulk density, etc. |
Securing the beginning of the supply chain through direct agricultural oversight and biotechnology research.
UniCare invests 10% of our annual net profit in research and development. In addition to optimizing and developing the existing natural plant extraction processes, we have also established a professional R&D department for the natural fermentation products. By increasing investment in natural fermentation products, we try to break through the traditional processes and disrupt industry development. UniCare has deep cooperation with Beijing University of Chemical Technology in the field of fermentation, jointly developing and transforming the new raw materials of pharmaceutical, cosmetic, and natural health products into mass-produced products.
In order to control raw materials more efficiently and with higher quality, a raw material procurement system has been established, which extends procurement to every piece of planting land and can trace the raw materials of each batch of products. The storage of raw materials is operated according to the advanced quality management system process, and the content of active ingredients, moisture, ash, heavy metals, pesticide residues and other items of raw materials are strictly controlled.
At the same time, in order to further ensure the high quality of important products, UniCare cooperated with planting farmers to establish ginkgo leaf planting bases, epimedium planting bases, phellodendron planting bases, olive leaf planting bases, etc. Some of these bases are planted strictly in accordance with the GACP management model. In addition, we cooperate with seedling research and development companies to develop high-content seedling cultivation, and cultivate better seedlings through hybridization or gene optimization, so as to continuously reduce unit costs to benefit users.
Eliminating market barriers through regional compliance documentation, warehousing, and customs optimization.
We provide comprehensive Active Substance Master Files (ASMF), Drug Master Files (DMF), and Certificates of Suitability (CEP) documentation. Our regulatory affairs team assists your formulation registrations directly with the US FDA, European Medicines Agency (EMA), and other local authorities.
To reduce supply-chain volatility, we coordinate with regional logistics hubs across North America, Germany, and Southeast Asia to offer Just-In-Time (JIT) delivery services. This lowers your inventory holding costs and eliminates long transoceanic shipping delays.
We work with globally accredited ISO/IEC 17025 laboratories (such as SGS, Eurofins, and NSF) to perform independent, third-party verify testing on active content ratios, pesticide screens, and residual organic solvents before dispatch.
Analyzing the raw material abundance, processing technology, and scale economics that benefit global buyers.
China is home to the world's largest natural populations of Ginkgo biloba trees. Our localized sourcing from structured plantations in Shandong, Jiangsu, and Guizhou provinces offers an uninterrupted supply of raw leaf material with high initial active constituent profiles.
By leveraging advanced dynamic countercurrent extraction loops, Chinese manufacturing facilities achieve high extraction yields with reduced energy consumption. This industrial scaling keeps our pricing competitive without sacrificing the purity or quality of the active fractions.
Our extraction facilities operate alongside specialized chemical and testing clusters, allowing for instant procurement of high-purity processing agents (such as USP-grade acetone) and direct access to state-of-the-art analytical equipment networks.
From microcirculatory pharmaceuticals to antioxidant cosmetic creams, explore how to formulate with our ingredients.
Standardized GBE powder is integrated into cognitive health capsules, focus-support tablets, and memory-enhancement blends. Safe, stable processing keeps the target active ratio (24% glycosides / 6% lactones) reliable across a 36-month shelf life.
Used as an active pharmaceutical ingredient (API) for products targeting peripheral vascular disorders, cognitive decline, tinnitus, and microcirculatory insufficiencies. Requires EU-GMP compliant acetone extraction to minimize ginkgolic acid content.
Ginkgo biloba's rich flavonoid profile acts as a powerful free radical scavenger in anti-aging creams. It helps soothe skin, improve hydration levels, and protect skin cells against environmental oxidative stress.
Incorporated into wellness beverages, ready-to-mix focus powders, and health shots. Requires highly water-soluble, organoleptically neutral grades that keep formulations clear and pleasant to consume.
Direct comparison of chemical limits and processing criteria demanded by international buyers.
| Parameter | USP Monograph Specification | European Pharmacopoeia (EP) | UniCare Premium Export Grade |
|---|---|---|---|
| Ginkgo Flavone Glycosides | 22.0% - 27.0% | 22.0% - 27.0% | 24.0% - 26.0% (HPLC Verified) |
| Terpene Lactones | 5.4% - 12.0% | 5.4% - 6.6% | 6.0% - 7.0% (HPLC Verified) |
| Ginkgolides A, B & C | 2.6% - 5.8% | 2.8% - 3.4% | 3.0% - 3.5% |
| Bilobalide | 2.6% - 5.8% | 2.6% - 3.2% | 2.8% - 3.2% |
| Ginkgolic Acids | < 5 ppm | < 5 ppm | < 1 ppm (Specialized Separation) |
| Residual Solvents (Acetone) | < 0.5% (5000 ppm) | < 0.5% (5000 ppm) | < 0.1% (1000 ppm) |
* Note: Achieving ginkgolic acid limits below 1 ppm requires a secondary adsorption chromatography column process. Contact UniCare's engineering department to request customized testing protocols for your batch requirements.
Get answers to common technical, regulatory, and logistics questions about Ginkgo Biloba sourcing.
The acetone-water system is the standard industrial solvent mixture recommended by both the European and US pharmacopoeias. Compared to ethanol extraction, acetone-water solvent combinations are highly selective. They efficiently extract target flavone glycosides and terpene lactones while minimizing the co-extraction of undesirable lipophilic alkylphenols (ginkgolic acids). UniCare operates the only EU-GMP standard acetone extraction line in China, ensuring maximum safety and purity.
For standard health foods and dietary supplements, the maximum limit defined by the USP and European Pharmacopoeia is 5 ppm (parts per million). However, for pharmaceutical applications or highly sensitive formulations, buyers often specify limits under 1 ppm. UniCare's advanced adsorption chromatography process easily meets both limits, with third-party testing confirmation available for every batch.
Yes, UniCare partners directly with regional growers to establish dedicated ginkgo leaf planting bases. Several of these bases are managed strictly in accordance with Good Agricultural and Collection Practices (GACP) protocols. This controls pesticide exposure, prevents heavy metal accumulation, and ensures sustainable harvest timing to optimize active phytochemical yields.
We provide a complete documentation package for each shipment, including Certificate of Analysis (COA) matching USP/EP parameters, Material Safety Data Sheets (MSDS), allergen statements, GMO-free statements, BSE/TSE statements, and geographical origin declarations. For pharmaceutical customers, we can assist with CEP validation and DMF files.
