Explore our premium selection of botanical extracts and bioactive ingredients trusted by leading global formulators.
Understanding the massive scale, applications, and procurement needs for Bromelain, Rutin, and Papain across modern industries.
Derived from pineapple stems (Ananas comosus), global B2B procurement seeks high enzymatic activity levels (ranging from 1200 GDU/g to 3000 GDU/g). Industries use Bromelain as a powerhouse anti-inflammatory, digestive agent, and protein tenderizer. Buyers emphasize low moisture, heavy metal exclusion, and micro-encapsulation options to ensure stability when blended with other active ingredients.
Rutin (quercetin-3-O-rutinoside) is harvested primarily from Sophora japonica. Procurement agents mandate strict conformity to international pharmacopeias (EP, USP, DAB, NF11). Key metrics include purity exceeding 95% or 98% by HPLC/UV, ultra-low residual solvents, and uniform particle sizes (micronized powders) to facilitate seamless tableting, capsule filling, and dissolution performance.
Extracted from the latex of green papaya (Carica papaya), Papain is highly valued for its wide-ranging pH stability and robust thermal resistance compared to other cysteine proteases. Large-scale industrial procurement focuses on enzymatic grades measured in TU, USP units, or MCU. Refined and ultra-filtrated grades are essential for high-end biomedical applications and stable dietary supplement complexes.
Modern dietary supplement brands and pharmaceutical manufacturers rarely formulate single-ingredient products. The true therapeutic value emerges from the complex synergy of Bromelain, Rutin, and Papain (the BRP Triad). By combining these, formulators achieve dual pathways for protein cleavage alongside capillary strengthening and systemic antioxidant response.
At UniCare, we address global formulating challenges by providing customized, pre-blended, or isolated compound solutions:
How our extraction processes and biotechnological systems are adapting to the next generation of industrial demands.
Transitioning from chemical precipitation to multi-stage ceramic membrane ultrafiltration. This retains original enzyme structures, completely avoids residual organic solvents, and increases the specific activity of Bromelain and Papain by 30% compared to traditional processes.
Utilizing high-end fluid bed spray dryers to coat active enzymes with protective lipid or cellulose matrices. This shields the active sites of Papain and Bromelain from degradation under elevated humidity and temperature environments during shipping.
Leveraging deep industrial partnerships to explore fermentation pathways that synthesize plant-derived biomolecules. This strategy reduces dependency on agricultural variations and stabilizes annual supply volume and pricing.
UniCare is a professional supplier of natural active ingredients. Our products are widely used in various fields such as dietary supplement, food, cosmetics and pharmaceuticals. We focus on product development and quality stability, and insist on growing together with our customers around the world.
UniCare has deep cooperation with several excellent Chinese manufacturers who have complete quality management system certifications, including but not limited to GMP, EUGMP, CEP, ISO9001, ISO22000, and HACCP. Each factory has independent testing capabilities and is equipped with advanced and efficient testing equipment to ensure the high quality and long-term stability of each batch of products.
Driving global health innovation through rigorous science and commitment to nature.
Discover and create the new value of herb, maximizing bioavailability and utility.
Continuous innovation and improvement of extraction metrics and purity standards.
With the most advanced technology to produce the highest quality products.
Make the employees happy and give back to the global and local community.
An inside look at China's most advanced plant extraction facilities.
UniCare attaches great importance to the hardware conditions of production equipment and has the largest and most advanced extraction factory in China. The entire production line in UniCare is controlled by a modern, intelligent, automatic control system. Until now, UniCare has built up two GMP workshops, containing six multi-functional extraction lines, among which there is the only production line for Ginkgo Biloba Extract of acetone process in the whole China. Here are several other production lines including fermentation production lines and Chinese medicine pieces. A total of 30,000 tons of various Chinese medicine plant raw materials can be processed each year.
The factory has passed full China GMP certification for herbal extracts and enzymes.
EU-GMP and CEP of Ginkgo Biloba Extract have been certified, proving our adherence to high-quality international regulatory standards.
All extraction lines adopt advanced PLC automation control systems for temperature, pressure, and flow rates.
Equipped with the most sophisticated concentration, separation, and purification systems in China.
Annual processing capability of 30,000 tons of Chinese medicine plant and raw materials.
Includes 3 annular dynamic countercurrent extraction lines (10t & 15t) and 2 multi-functional extraction lines (32 tanks, 6m³ each).
Features the only acetone process extraction line for Ginkgo Biloba in China meeting EU GMP standards.
Features six massive 20-ton fermentation tanks for producing enzyme-modified plant products.
Ensuring absolute identity, purity, and activity stability for every batch through CNAS laboratories.
Our analytical laboratory covers all crucial parameters necessary to satisfy international pharmaceutical and dietary regulations:
We invest heavily in state-of-the-art diagnostic platforms to remove uncertainty from the supply chain:
| Instrument Model & Brand | Quantity | Application Area |
|---|---|---|
| UHPLC, Agilent 1290 | 2 Sets | High-throughput purity assays |
| HPLC, Agilent 1260 | 4 Sets | Active ingredient and marker identification |
| HPLC, Shimadzu LC-20AT | 2 Sets | Standardized assays and stability verification |
| ELSD, Shimadzu 2000ES | 2 Sets | Detecting compounds lacking UV chromophores |
| Shimadzu GC-2010 | 1 Set | Residual solvent analyses |
| Shimadzu AA-7000 (Atomic Absorption) | 1 Set | Heavy metal analysis (Pb, As, Hg, Cd) |
| Comprehensive Testing & Verification Protocols | |
|---|---|
| Active Ingredient Analysis | Assay testing, microscopic and chemical identity verification. |
| Hazardous Substance Analysis | Heavy metals (ICP-MS), pesticide residue screening, residual organic solvent chromatography. |
| Microbe Analysis | Total aerobic microbial count (TAMC), total yeasts and molds count (TYMC), specific pathogen testing. |
| Raw Material Control | Pesticide residue testing on farm crops, GMO checking, allergen analysis, country of origin tracking. |
| Laws & Regulations Confirmation | Continuous regulatory reviews to ensure alignment with GB, FDA, EU, and JP specifications. |
| Stability Test | Real-time and accelerated stability studies in controlled climatic chambers to confirm expiration dates. |
From hybridized seed selection to advanced bio-fermentation partnerships.
UniCare invests 10% of our annual net profit directly into research and development. In addition to optimizing traditional plant extraction methodologies, we maintain a designated R&D wing focusing on natural fermentation platforms. Through research in synthetic biology and enzymatic modification, we aim to modernize extraction and scale active biomolecule production.
We work in collaboration with the Beijing University of Chemical Technology in the field of industrial fermentation, co-developing high-yield cosmetic, health, and pharmaceutical active ingredients ready for commercialization.
To control quality at the root, UniCare established a strict raw material sourcing protocol extending directly to individual farms. Raw materials can be fully traced back to their batch seeds, soil records, and cultivation fields. Storage is governed by rigid parameters assessing botanical identity, humidity levels, ash limits, heavy metals, and pesticide residues.
We operate collaborative agricultural farming networks, establishing designated crop bases for Ginkgo leaf, Epimedium, Phellodendron, and Olive leaf. Select bases run strictly under Good Agricultural and Collection Practices (GACP) protocols. Furthermore, we develop improved crop strains in partnership with specialized research institutes to optimize extraction yield and lower final costs.
Assuring predictable product pipelines amidst shifting economic and agricultural realities.
Global logistics for active proteases like Bromelain and Papain face major hurdles concerning ambient heat and humidity. Excessive thermal exposure during maritime transport causes irreversible denaturation of enzyme structures, reducing potency below target specifications by the time it reaches client facilities.
UniCare tackles these distribution challenges through a robust supply framework:
| Compliance Standard | Geographic Jurisdiction | Relevance to Buyers |
|---|---|---|
| EU-GMP / CEP | European Union & Globally | Authorizes use in high-end pharmaceutical formulations. |
| FDA Registration | United States | Ensures entry compliance for functional food and supplement markets. |
| ISO 22000 & HACCP | International | Confirms strict preventive hazard controls throughout processing. |
| Kosher / Halal | Multi-regional | Broadens consumer market accessibility. |
Addressing technical inquiries regarding the specifications, stability, and handling of our enzyme and flavonoid complexes.
We confirm active levels using pharmacopeial-compliant assays. Bromelain activity is quantified via Gelatin Digesting Units (GDU/g) or Milk Clotting Units (MCU/mg) based on gelatin hydrolysis rates. Papain activity is verified via casein digestion protocols (USP or FCC units). All testing runs on calibrated UV-Vis spectrophotometers against reference standards.
Enzymes like Bromelain and Papain are sensitive to high moisture and shear forces. We supply enteric-coated granulated powders and micro-encapsulated formats using organic polymers or clean-label lipids. This prevents premature activation, controls dusting during manufacturing, and extends shelf-life.
Our Rutin is extracted from the dried buds of Sophora japonica. Purity is validated using High-Performance Liquid Chromatography (HPLC) to verify compliance with European Pharmacopoeia (EP) and USP specifications, consistently yielding assays of 95% to 98% on an anhydrous basis.
Every batch undergoes routine testing via Inductively Coupled Plasma Mass Spectrometry (ICP-MS) to guarantee heavy metal values (lead, cadmium, mercury, and arsenic) fall well below EPA and EFSA limits. Pesticide residues are analyzed through GC-MS-MS systems, satisfying global regulatory standards.
Sourcing high-purity active ingredients for pharmaceutical and food production lines.
