Premium botanical extracts manufactured under strict international quality guidelines
Berberine, a natural quaternary ammonium alkaloid found in plants such as Berberis aristata and Coptis chinensis, is globally recognized for its profound impact on metabolic health, insulin sensitivity, and AMP-activated protein kinase (AMPK) activation. However, standard Berberine Hydrochloride (HCL) faces severe pharmacokinetic limitations. Scientific literature indicates that its oral bioavailability is typically under 5% due to poor aqueous solubility, low intestinal membrane permeability, and active efflux mediated by P-glycoprotein (P-gp) in the gut mucosa.
As a leading research-driven factory partner, we address these physiological barriers through two main technological routes:
UniCare is a professional supplier of natural active ingredients. Our products are widely used in various fields such as dietary supplement, food, cosmetics and pharmaceuticals. We focus on product development and quality stability, and insist on growing together with our customers around the world.
UniCare has deep cooperation with several excellent Chinese manufacturers who have complete quality management system certifications, including but not limited to GMP, EUGMP, CEP, ISO9001, ISO22000, and HACCP. Each factory has independent testing capabilities and is equipped with advanced and efficient testing equipment to ensure the high quality and long-term stability of each batch of products.
Bridging traditional plant wisdom with state-of-the-art bio-manufacturing processes
Unlocking molecular efficacy through advanced processing and micro-encapsulation techniques.
Constantly refining extraction purity, particle size optimization, and yield efficiency.
Equipped with high-performance chromatographs and automated control structures.
Fostering local agricultural ecosystems and driving sustainable economic loops.
To produce high-purity, bioavailable Berberine at scale, our factories implement a dual-phase extraction and formulation roadmap. This ensures that the active phytoconstituents are not only stabilized but modified to optimize human intestinal transit times.
| Technological Stage | Process Details | Target Output / Specification |
|---|---|---|
| Raw Material Sourcing | Cultivated in GACP certified organic bases (Phellodendron amurense & Berberis aristata roots). | Identified raw material with high alkaloid marker content (>3.5%). |
| Dynamic Countercurrent Extraction | Automated industrial countercurrent extraction lines operating under optimized heat and vacuum pressure. | Crude berberine concentrate free of organic residues. |
| Refinement & Crystallization | Multiple filtration loops and solvent crystallization to remove unwanted plant tannins and waxes. | Berberine HCL > 97% or 98% purity (USP/EP Grade). |
| Bioavailability Transformation | Hydrogenation catalysis under controlled pressure to form Dihydroberberine (DHB), or Liposomal complexation. | DHB powder with enhanced water solubility and high gut absorption profiles. |
| Standardization & Testing | Testing through Agilent 1290 UHPLC and ICP-MS for heavy metals and solvent levels. | Bulk powders conforming to strict FDA and European botanical regulations. |
The botanical market is moving rapidly from raw plant powders to functionally targeted extracts. Our research department is currently working on nano-micellar encapsulation of berberine, which has shown in pilot studies to yield up to 10-fold oral absorption rates. Additionally, we are exploring synergetic combinations of bioavailable berberine with other natural metabolic activators, such as Chromium Picolinate and Cinnamon polyphenols, providing turnkey raw material blends for dietary supplement manufacturers globally.
UniCare attaches great importance to the hardware conditions of production equipment and has the largest and most advanced extraction factory in China. The entire production line in UniCare is controlled by a modern, intelligent, automatic control system.
Until now, UniCare has built up two GMP workshops, containing six multi-functional extraction lines, among which there is the only production line for Ginkgo Biloba Extract of acetone process in the whole China. Here are several other production lines including fermentation production lines and Chinese medicine pieces. A total of 30,000 tons of various Chinese medicine plant raw materials can be processed each year.
In the post-pandemic supply chain landscape, global dietary supplement brands demand more than just premium quality; they require regulatory safety, constant volume availability, and localized logistic support. UniCare operates as a fully integrated supplier with direct control over primary raw materials, mitigating geopolitical and climate-based raw material fluctuations.
Our extraction facilities are located in close geographical proximity to key botanical growing regions in China. This lowers internal carbon footprints, protects raw material freshness, and guarantees reliable capacity. By using local high-efficiency shipping ports and established raw material stockpiles, we ensure a constant supply stream of bioavailable berberine to distributors in the US, Europe, and Asia-Pacific, even during peak global demand periods.
Navigating the regulatory landscape of different regions is essential for the commercial success of our clients. Our dedicated compliance department works closely with regional registration experts to ensure that every batch of Bioavailable Berberine complies with the target market's laws:
United New Life (UniCare) has established a leading and complete quality control system, and strictly controls the high quality of products in accordance with the quality system.
With advanced testing instruments, strict control of product quality, to provide every customer with high quality products. Detectable items are: Signature component detection (HPLC or UV), solvent residues GC, pesticide residues (organochlorine detection) GC-MS-MS, heavy metals (lead, arsenic, mercury, cadmium, copper) ICP-MS microscopic identification, moisture, dry weight loss, ash, microbial limits, thin layer identification, weighing, conductivity, PH, sulfur dioxide residue, routine detection, etc.
Our state-of-the-art CNAS-qualified laboratory houses the following high-precision testing configurations:
| Instrument Type | Brand / Configuration | Quantity Available |
|---|---|---|
| UHPLC Ultra-High Performance Liquid Chromatograph | Agilent 1290 | 2 units |
| HPLC High Performance Liquid Chromatography Set | Agilent 1260 | 4 units |
| HPLC High Performance Liquid Chromatograph | Shimadzu LC-20AT | 2 units |
| HPLC Liquid Chromatograph | Dionex CU3000 | 2 units |
| Evaporative Light Scattering Detector (ELSD) | Shimadzu 2000ES | 2 units |
| Gas Chromatograph (GC) for solvent residue testing | Shimadzu GC-2010 | 1 unit |
| Atomic Absorption Spectrophotometer (AAS) | Shimadzu AA-7000 / AA-700 | 1 unit |
UniCare invests 10% of our annual net profit in research and development. In addition to optimizing and developing the existing natural plant extraction process, we have also established a professional R&D department for natural fermentation products. By increasing investment in natural fermentation products, we try to break through traditional processes and drive industry innovation.
UniCare has deep cooperation with Beijing University of Chemical Technology in the field of fermentation, jointly developing and transforming new raw materials for pharmaceuticals, cosmetics, and natural health products into mass-produced applications.
In order to control raw materials more efficiently and with higher quality, a raw material procurement system has been established, which extends procurement directly to each cultivation plot and allows tracing the raw materials of each batch of products. Raw material storage is operated according to our quality management system process, strictly controlling active ingredient content, moisture, ash, heavy metals, and pesticide residues.
At the same time, to ensure the high quality of key products, UniCare collaborated with growers to establish ginkgo leaf, epimedium, phellodendron, and olive leaf planting bases. Some of these bases are operated strictly in accordance with the GACP management model. In addition, we cooperate with seedling research and development companies to cultivate high-yield seedlings through hybrid or genetic optimization, continuously lowering production costs for our clients.
A visual tour of our production facility, packing, and quality verification workflows
Technical and regulatory insights for supply chain managers and product developers
High-purity botanical raw ingredients sourced globally for manufacturing excellence
