Explore our primary selection of scientifically validated, highly bioavailable plant extracts designed for the global food, nutraceutical, and pharmaceutical processing sectors.
Berberis Vulgaris, historically recognized for its physiological versatility, has become a core biological agent in international pharma-nutrition. Marketed across diverse formats—including 200CH homeopathic solutions, standardized alkaloid-rich fractions, and refined botanical isolates—it addresses cellular AMPK pathway triggers, insulin sensitivity, and lipid transport mechanisms.
The sourcing of high-purity Berberis Vulgaris extracts requires rigorous control over alkaloid variations. Many standard factories struggle with seasonal changes in raw plant material and residual solvents. As a leading manufacturer, UniCare addresses these constraints by securing dedicated cultivation zones and utilizing advanced countercurrent extraction columns to produce standardized yields of critical biomolecules, such as berberine, oxyacanthine, and berbamine.
Industrial buyers must distinguish between low-dose preparations (such as Berberis Vulgaris 200C/200CH) and high-potency dry extracts standardizing active alkaloids like Berberine. Both preparations rely on strict extraction steps, GMP processing, and highly controlled dilutions to ensure efficacy, purity, and absolute safety for the end consumer.
UniCare is a professional supplier of natural active ingredients. Our products are widely used in various fields such as dietary supplement, food, cosmetics and pharmaceuticals. We focus on product development and quality stability, and insist on growing together with our customers around the world.
UniCare has deep cooperation with several excellent Chinese manufacturers who have complete quality management system certifications, including but not limited to GMP, EUGMP, CEP, ISO9001, ISO22000, and HACCP. Each factory has independent testing capabilities and is equipped with advanced and efficient testing equipment to ensure the high quality and long-term stability of each batch of products.
Understanding chemical fingerprints and concentration limits is essential for procurement managers looking to source Berberis Vulgaris extracts.
Standardized batches targeting total alkaloids calculated as Berberine (up to 97-98% pure via HPLC/UV). This high yield serves as a benchmark for premium pharmaceutical formulations.
ICP-MS quantification guarantees levels far below global regulatory thresholds (Lead < 0.5 ppm, Arsenic < 0.5 ppm, Mercury < 0.1 ppm, Cadmium < 0.1 ppm).
Fully compliant with ICH Q3C Guidelines. Standard extraction profiles utilize ethanol and water systems, minimizing chemical residue while avoiding Class 1 and Class 2 toxic solvents.
Screened against 300+ common agricultural compounds using GC-MS-MS to meet stringent EU regulations and USDA organic profiles.
Why Choose Us?
UniCare attaches great importance to the hardware conditions of production equipment and has the largest and most advanced extraction factory in China. The entire production line in UniCare is controlled by a modern, intelligent, automatic control system.
Until now, UniCare has built up two GMP workshops, containing six multi-functional extraction lines, among which there is the only production line for Ginkgo Biloba Extract of acetone process in the whole China. Here are several other production lines including fermentation production lines and Chinese medicine pieces. A total of 30,000 tons of various Chinese medicine plant raw materials can be processed each year.
The facility has passed strict China GMP certification standards, ensuring batch-to-batch quality consistency.
Certified EU-GMP and CEP lines, ensuring compatibility with strict European pharmaceutical directives.
All extraction production lines adopt modern, intelligent, and automated control networks.
Own the most advanced large-scale extraction equipment currently active in China.
Annual processing of 30,000 tons of Chinese medicine plant raw materials at peak operations.
Six state-of-the-art lines, including annular dynamic countercurrent and multi-functional extraction tanks.
Own the only acetone process extraction line for Ginkgo Biloba in China meeting EU GMP specifications.
Six large fermentation tanks (20 tons capacity each) dedicated to enzymatically modified botanicals.
Take a virtual tour of our production facility. We use advanced technology to maintain high quality across all product lines.
When importing raw botanical ingredients like Berberis Vulgaris extracts, adhering to local regulations is critical for a smooth supply chain. Different jurisdictions view these extracts through different regulatory lenses:
UniCare supports international distributors by providing complete documentation packages. These include Certificate of Analysis (CoA) batches, Gas Chromatography-Mass Spectrometry (GC-MS) logs, and full Allergen declarations. Our compliance team simplifies importing to help you avoid customs clearance issues.
| Compliance Parameter | Standard Threshold | UniCare Compliance Action |
|---|---|---|
| Lead (Pb) | < 1.0 ppm | Verified batch level < 0.2 ppm by ICP-MS |
| Pesticide Residue | EPA / EFSA limits | Multi-residue screening (300+ components) |
| Total Aerobic Count | < 1,000 cfu/g | Batch pasteurization and micro testing |
| Identity Verification | 100% botanical match | Validated by HPTLC identification protocols |
UniCare has established a leading and complete quality control system, and strictly controls the high quality of products in accordance with the quality system.
With advanced testing instruments, strict control of product quality, to provide every customer with high quality products. Detectable items are: Signature component detection (HPLC or UV), solvent residues GC, pesticide residues (organochlorine detection) GC-MS-MS, heavy metals (lead, arsenic, mercury, cadmium, copper) ICP-MS microscopic identification, moisture, dry weight loss, ash, microbial limits, thin layer identification, weighing, conductivity, PH, sulfur dioxide residue, routine detection, etc.
| UniCare Partner Quality Control Management System | |
|---|---|
| Active Ingredient Analysis | Assay, identification validation by HPLC, UHPLC, and UV spectrophotometry. |
| Hazardous Substance Analysis | Heavy metals, pesticide residue, solvent residue, and PAH analysis. |
| Microbe Analysis | Bacterium, Escherichia coli, Yeast & mould, and specific pathogen testing. |
| Raw Material Control | Pesticide residue, allergen declaration, GMO screening, and raw material geographic tracing. |
| Laws & Regulations Confirmation | Continuous research of pharmacopoeia requirements in China, US, EU, and destination markets. |
| Stability Test | Accelerated and long-term stability studies to guarantee shelf life. |
| Physical/Chemical Testing | pH value, moisture, ash, optical rotation, particle size distribution, bulk density, etc. |
Our Central Lab spans over a large testing area and is qualified by CNAS. It is equipped with advanced analytical machinery, including:
| Equipment Category | Quantity / Detail |
|---|---|
| UHPLC, Agilent 1290 | 2 Sets (Ultra-high performance liquid chromatography) |
| HPLC, Agilent 1260 | 4 Sets (High performance liquid chromatography) |
| HPLC, Shimadzu LC-20AT | 2 Sets (High accuracy assay profiling) |
| ELSD, Shimadzu 2000ES | 2 Sets (Evaporative light scattering detectors) |
| Shimadzu GC-2010 | 1 Set (Gas chromatography for volatile residues) |
| Shimadzu AA-700 | 1 Set (Atomic absorption system for heavy metals) |
UniCare invests 10% of our annual net profit in research and development. In addition to optimizing and developing the existing natural plant extraction process, we have also established a professional R&D department for the natural fermentation products. By increasing investment in natural fermentation products, we try to break through the traditional processes and disrupt industry development.
UniCare has deep cooperation with Beijing University of Chemical Technology in the field of fermentation, jointly developing and transforming the new raw materials of pharmaceutical, cosmetic, and natural health products into mass-produced products.
In order to control raw materials more efficiently and with higher quality, a raw material procurement system has been established, which extends procurement to every piece of planting land and can trace the raw materials of each batch of products. The storage of raw materials is operated according to the advanced quality management system process, and the content of active ingredients, moisture, ash, heavy metals, pesticide residues and other items of raw materials are strictly controlled.
At the same time, in order to further ensure the high quality of important products, UniCare cooperated with planting farmers to establish ginkgo leaf planting bases, epimedium planting bases, phellodendron planting bases, olive leaf planting bases, etc. Some of these bases are planted strictly in accordance with the GACP management model. In addition, we cooperate with seedling research and development companies to develop high-content seedling cultivation, and cultivate better seedlings through hybridization or gene optimization, so as to continuously reduce unit costs to benefit users.
Traditional static steeping processes are being replaced by automated dynamic countercurrent extraction. By utilizing localized temperature adjustments and precise control over raw material contact times, we increase alkaloid extraction efficiency from the roots and bark of Berberis Vulgaris while saving energy.
The industry is moving toward green extraction methods. At UniCare, we minimize chlorinated hydrocarbon exposure by using food-grade ethanol and water-based extraction systems. This ensures our extracts comply with European Union pesticide and solvent regulations.
In collaboration with Beijing University of Chemical Technology, we are researching enzymatic modification and microbial fermentation to convert precursor compounds into high-purity alkaloids. This technology helps stabilize raw material costs against agricultural fluctuations.
Explore our secondary selection of specialized botanical extracts, manufactured under strict quality standards to support your formulation requirements.
