Chinese Goldthread, scientifically identified as Coptis chinensis (and locally known as Huanglian), is a cornerstone botanical ingredient within the international phytomedicine, nutraceutical, and pharmaceutical supply chains. Renowned for its extraordinarily high concentration of isoquinoline alkaloids—principally Berberine, along with Coptisine, Palmatine, and Jatrorrhizine—Coptis chinensis serves as a vital component in modern therapeutic formulations.
In the global market, industrial applications of Chinese Goldthread have expanded dramatically beyond traditional herbal preparations. Today, multi-national pharmaceutical firms and high-end dietary supplement manufacturers utilize standardized Coptis chinensis extracts to support metabolic health, cardiovascular functions, and robust microbial defense mechanisms. As clinical trials continue to validate berberine's efficacy in managing glycemic pathways, global demand has surged, prompting strict standards for sustainable cultivation and chemical fingerprint consistency.
UniCare is a professional supplier of natural active ingredients. Our products are widely used in various fields such as dietary supplement, food, cosmetics and pharmaceuticals. We focus on product development and quality stability, and insist on growing together with our customers around the world.
UniCare has deep cooperation with several excellent Chinese manufacturers who have complete quality management system certifications, including but not limited to GMP, EUGMP, CEP, ISO9001, ISO22000, and HACCP. Each factory has independent testing capabilities and is equipped with advanced and efficient testing equipment to ensure the high quality and long-term stability of each batch of products.
Our principles drive our technological integration, guaranteeing that each shipment meets international pharmaceutical requirements.
Uncovering and unlocking the latent chemical properties of raw herbs to resolve formulation challenges.
Unremitting optimization and continuous refinement of molecular separations and refining processes.
Deploying the most advanced dynamic countercurrent pipelines to manufacture high-yield active isolates.
Enriching the livelihoods of agricultural farming partners while safeguarding eco-sustainability.
UniCare attaches great importance to the hardware conditions of production equipment and has the largest and most advanced extraction factory in China. The entire production line in UniCare is controlled by a modern, intelligent, automatic control system.
Until now, UniCare has built up two GMP workshops, containing six multi-functional extraction lines, among which there is the only production line for Ginkgo Biloba Extract of acetone process in the whole China. Here are several other production lines including fermentation production lines and Chinese medicine pieces. A total of 30,000 tons of various Chinese medicine plant raw materials can be processed each year.
The entire fabrication factory has successfully completed and passed the rigorous China GMP certification process.
Our Ginkgo Biloba Extract lines strictly adhere to EU-GMP and hold official CEP certifications.
Every single botanical extraction line is fully regulated by advanced, real-time distributed automation platforms.
We own and deploy China's most efficient herbal extraction and vacuum-concentration machinery array.
Scalable processing capability ensures raw material price security and bulk supply reliability.
Comprises 3 annular dynamic countercurrent setups (10T & 15T) and 2 multi-functional extraction batteries (32 units of 6m³).
Own the only acetone process extraction line for Ginkgo Biloba Extract in China that meets the EU GMP standards.
Equipped with six 20-ton bio-fermentation bioreactors designed specifically for enzymatic and customized products.
Take a virtual walk through our ISO & GMP compliant production, formulation and logistics centers.
United New Life (UniCare) has established a leading and complete quality control system, and strictly controls the high quality of products in accordance with the quality system. With advanced testing instruments and strict control of product quality, we provide every customer with premium products.
Our analytical suites support testing for various parameters: Signature component detection (HPLC or UV), solvent residues (GC), pesticide residues (organochlorine detection GC-MS-MS), heavy metals (lead, arsenic, mercury, cadmium, copper by ICP-MS), microscopic identification, moisture, dry weight loss, ash content, microbial limits, thin layer chromatography (TLC) identification, density, conductivity, pH values, and sulfur dioxide residues.
Our analytical validation relies on highly calibrated instruments, including: Two UHPLC Agilent 1290 ultra-high performance liquid chromatographs, four HPLC Agilent 1260 high performance liquid chromatography sets, two HPLC Shimadzu LC-20AT systems, two HPLC Dionex UltiMate 3000, two Shimadzu evaporative light scattering detectors (ELSD) 2000ES, one Shimadzu GC2010 gas chromatograph, and one Shimadzu AA-7000 atomic absorption spectrophotometer system.
| Quality Control Domain | Specific Analytical Items & Validation Parameters |
|---|---|
| Active Ingredient Analysis | Assay testing, chromatographic identification, bioactive component profiling. |
| Hazardous Substance Analysis | Heavy metals (ICP-MS), multi-pesticide residue screenings, organic volatile solvent residues. |
| Microbe Analysis | Total viable aerobic plate counts, Escherichia coli, Salmonella, Yeast & mold, specific pathogens. |
| Raw Material Control | Field pesticide profiling, allergen validation, non-GMO compliance, geographical origin traceability. |
| Laws & Regulations Confirmation | Detailed documentation audit and compliance alignment with target import regions (FDA, EFSA, NMPA). |
| Stability Test | Real-time and accelerated stability studies to guarantee shelf life integrity. |
| Physical and General Assays | pH value, moisture content, total ash, optical rotation, bulk/tapped density, mesh size distribution. |
| Equipment Type / Model | Available Units | Industrial Analytical Focus |
|---|---|---|
| UHPLC, Agilent 1290 | 2 Units | Ultra-rapid chromatographic fingerprinting, high-throughput active assays. |
| HPLC, Agilent 1260 | 4 Units | Routine identification, compound isolation, quantitative assay of active alkaloids. |
| HPLC, Shimadzu LC-20AT | 2 Units | Standardized release testing and active substance verification. |
| ELSD, Shimadzu 2000ES | 2 Units | Detection of non-UV absorbing active components and lipids. |
| Shimadzu GC-2010 | 1 Unit | Organic volatile impurities, residual solvents (Hexane, Acetone, Ethanol). |
| Shimadzu AA-7000 (AAS) | 1 Unit | Trace heavy metal analysis (Pb, As, Hg, Cd). |
UniCare invests 10% of our annual net profit in research and development. In addition to optimizing and developing the existing natural plant extraction process, we have also established a professional R&D department for natural fermentation products. By increasing investment in natural fermentation products, we try to break through the traditional processes and disrupt industry development.
UniCare has deep cooperation with Beijing University of Chemical Technology in the field of fermentation, jointly developing and transforming the new raw materials of pharmaceutical, cosmetic, and natural health products into mass-produced products.
In order to control raw materials more efficiently and with higher quality, a raw material procurement system has been established, which extends procurement to every piece of planting land and can trace the raw materials of each batch of products. The storage of raw materials is operated according to the advanced quality management system process, and the content of active ingredients, moisture, ash, heavy metals, pesticide residues and other items of raw materials are strictly controlled.
At the same time, in order to further ensure the high quality of important products, UniCare cooperated with planting farmers to establish ginkgo leaf planting bases, epimedium planting bases, phellodendron planting bases, olive leaf planting bases, etc. Some of these bases are planted strictly in accordance with the GACP management model. In addition, we cooperate with seedling research and development companies to develop high-content seedling cultivation, and cultivate better seedlings through hybridization or gene optimization, so as to continuously reduce unit costs to benefit users.
As international regulations tighten around the import of botanical ingredients, procurement managers face hurdles with heavy metal parameters, pesticide residues, and PAHs (Polycyclic Aromatic Hydrocarbons). The market demand for Coptis chinensis extract is shifting towards high-purity, solvent-free powders that comply with European Pharmacopoeia (EP) and United States Pharmacopeia (USP) standards.
As a leading Chinese Goldthread supplier, UniCare has engineered solutions to address these B2B requirements. Our extraction facilities utilize pure water and pharmaceutical-grade ethanol solvent systems, eliminating concerns over toxic solvent residue contamination. Furthermore, our raw material planting bases in Sichuan and Chongqing—the geographic epicenters of prime Coptis chinensis cultivation—allow us to manage agricultural inputs, guaranteeing low pesticide profiles before the raw root ever enters our extraction tanks.
We trace every single drum back to the specific batch of raw materials and cultivation plot, ensuring easy auditing and supply security.
Capable of producing specific active profiles tailored to client specifications, whether they require high Berberine, high Coptisine, or customized ratio outputs.
With an annual capacity exceeding 30,000 tons of processed herbs, we provide price stability and buffer stocks for large-scale pharmaceutical contracts.
Our standard Chinese Goldthread Extract is standardized to contain 10% to 98% Berberine HCl by HPLC. We also supply raw extract ratios (e.g., 4:1, 10:1, 20:1) and custom-profile extracts with high fractions of secondary alkaloids such as Coptisine, Palmatine, and Jatrorrhizine, depending on client formulation requirements.
Every production batch undergoes testing at our CNAS-qualified laboratory using Shimadzu AA-7000 Atomic Absorption and ICP-MS systems. We guarantee limits conform to the strictest EU and US regulations: Lead (Pb) < 3.0 ppm, Arsenic (As) < 1.0 ppm, Cadmium (Cd) < 1.0 ppm, and Mercury (Hg) < 0.1 ppm.
Yes. We primarily utilize food-grade ethanol and purified water. Solvent residual profiles are audited using gas chromatography (GC-2010). All solvent limits are strictly within the thresholds defined by the USP <467> and EP Guidelines on residual solvents.
Our standard MOQ for commercial botanical extracts starts at 25 kg (packaged in standard fiber drums with double PE inner lining bags). Lead times vary from 7 to 15 days for in-stock standardized extracts, and up to 30 days for customized formulations requiring special cultivation batch selection.
