Explore our premium range of highly standardized natural active ingredients manufactured in GMP-certified facilities for global export.
Ginkgo Biloba Extract EGb 761 is widely recognized as the preeminent standardized extract of Ginkgo biloba leaves, clinically demonstrated to alleviate symptoms of cognitive decline, age-related dementia, microcirculatory insufficiency, peripheral arterial occlusive disease (PAOD), and neurosensory disorders including tinnitus and vertigo. Sourced from botanical plantations governed under strict Good Agricultural and Collection Practices (GACP), this compound requires precise fractionation techniques to maintain its complex multi-constituent chemical profile while eliminating toxic native components like ginkgolic acids.
The therapeutic matrix of authentic EGb 761 is meticulously engineered. It is standardized to contain 22.0% to 27.0% Ginkgo Flavone Glycosides (primarily quercetin, kaempferol, and isorhamnetin) and 5.4% to 6.6% Terpene Lactones, composed of 2.8% to 3.4% Ginkgolides A, B, and C, and 2.6% to 3.2% Bilobalide.Crucially, the concentration of cytotoxic alkylphenols (ginkgolic acids) is strictly limited to less than 5 ppm (and optimized in our facility to <1 ppm) to prevent immunotoxic and allergenic reactions, satisfying both the European Pharmacopoeia (EP) and the United States Pharmacopeia (USP) monographs.
UniCare stands as a premier professional supplier of natural active ingredients, serving global industry leaders in dietary supplements, functional foods, cosmetics, and pharmaceuticals. Our mission is built on continuous technical advancement, uncompromising quality control, and structural stability. We are committed to developing long-term partnerships, growing synergistically with our clients across the globe.
We work in deep strategic alignment with exceptional Chinese manufacturers holding complete quality management certifications, including but not limited to GMP, EU-GMP, CEP, ISO9001, ISO22000, and HACCP. Each partner factory possesses fully independent analytical capabilities and is outfitted with the industry’s most sophisticated, high-performance testing instruments to guarantee that every manufactured batch of Ginkgo Extract meets strict international pharmaceutical regulations.
Harnessing automated, state-of-the-art manufacturing facilities to deliver maximum yields and high-purity active ingredients.
UniCare invests heavily in high-performance production equipment and operates the largest, most technologically advanced extraction factory in China. The entire production sequence is controlled by a modern, intelligent, automated SCADA control system, ensuring consistent process parameters across every run.
Our extraction campus houses two state-of-the-art GMP workshops, containing six multi-functional extraction lines. Crucially, we own and operate the only production line for Ginkgo Biloba Extract via the acetone process in all of China that is fully compliant with EU-GMP and CEP regulations. This represents a massive strategic advantage for buyers requiring authentic, pharmaceutical-grade EGb 761 standard compliance.
Our entire extraction facility has passed rigorous audits to secure national China-GMP certification for active raw materials.
Our Ginkgo Biloba Extract holds validated EU-GMP and CEP certifications, allowing seamless access to the EU pharmaceutical market.
All active extraction runs are monitored by automated process loop controls to minimize batch-to-batch variability.
Featuring custom-built, highly efficient industrial dynamic extractors, providing higher yields and cleaner fractions.
We process up to 30,000 tons of medicinal herb raw materials per year, supporting large-scale global procurement contracts.
Equipped with three annular dynamic countercurrent extraction lines (10T & 15T) and two multi-functional extraction setups (32 tanks, 6m³ each).
The only acetone process line in China engineered to meet the highest EU GMP standards for Ginkgo Extract.
Utilizing six 20-ton fermentation tanks to facilitate enzyme modifications and bio-conversions for enhanced bioavailability.
A visual tour across our advanced manufacturing suites, R&D testing labs, and raw botanical processing zones.
A comprehensive system of validation, keeping our botanical products strictly aligned with EP, USP, and CP pharmacopeias.
At UniCare, quality is not a retrofitted check; it is built into the process. We have established an industry-leading quality control framework. Using ultra-precise analytical instruments, we run exhaustive assays on every single batch of Ginkgo Biloba Extract EGb 761, validating fingerprint consistency, trace pesticide clearances, and heavy metal concentrations.
Our analytical capacity is driven by a CNAS certified central laboratory, deploying state-of-the-art testing equipment including: two UHPLC Agilent 1290 ultra-high performance liquid chromatographs, four HPLC Agilent 1260 systems, two HPLC Shimadzu LC-20AT systems, two HPLC Dionex UltiMate 3000 systems, two Shimadzu ELSD 2000ES detectors, one Shimadzu GC-2010 gas chromatograph, and one Shimadzu AA-7000 atomic absorption system. This array enables us to execute advanced diagnostic techniques including HPLC/UV quantification, GC head-space solvent evaluation, and ICP-MS micro-contamination screening.
| Analytical Category | Specific Testing Parameters & Action Ranges |
|---|---|
| Active Constituent Assays | Ginkgo flavone glycosides (22.0%-27.0%), terpene lactones (5.4%-6.6%), bilobalide quantification, Kaempferol/Quercetin ratio check. |
| Hazardous Substances | ICP-MS heavy metals (Pb < 0.5ppm, As < 0.5ppm, Hg < 0.1ppm, Cd < 0.1ppm), residual solvents (GC-MS limits for acetone/ethanol), pesticide residues. |
| Microbial Limits | Total aerobic microbial count (TAMC) < 1000 CFU/g, total combined yeasts/molds (TYMC) < 100 CFU/g, negative Salmonella, E. coli, and Staphylococcus aureus. |
| Raw Material Traceability | Identity confirmation via TLC, DNA barcoding authentication of leaf origin, GACP cultivation site pesticide audits. |
| Regulatory & Compliance Checks | Conformity validation with US FDA, EFSA, CFDA regulations, validation of CEP, EU-GMP dossiers, DMF filings, and kosher/halal parameters. |
| Physical Characteristics | Particle size distribution, bulk density, tap density, moisture content (loss on drying < 5.0%), ash value (< 1.0%), pH range, and solubility profiles. |
Controlling quality from the seed: How our raw material cultivation bases and academic research partnerships secure superior active ingredient outputs.
We reinvest 10% of our annual net profit directly back into R&D. Beyond updating extraction steps, our dedicated team explores innovative bio-fermentation processes to bypass traditional constraints.
We work directly with growers to operate specialized Ginkgo biloba, Epimedium, Phellodendron, and Olive leaf plantations. These sites are run strictly according to Good Agricultural and Collection Practices (GACP) to guarantee chemical uniformity.
We partner closely with top research institutions, including the Beijing University of Chemical Technology, to develop and scale up innovative active ingredients from clinical pilot phases to industrial mass production.
By coordinating with seedling developers, we cultivate high-potency cultivars through traditional hybridization and genomic optimization. This research produces parent lines that yield up to 30% higher active flavone glycosides in their leaves compared to wild strains, helping us lower raw material costs and pass those savings directly on to our partners.
Addressing the critical logistical, regulatory, and localization concerns of international pharmaceutical and nutraceutical buyers.
Exporting active ingredients globally demands precise compliance. We provide complete documentation, including CEP, US DMF registration numbers, EU-REACH registration, and full stability testing dossiers. Our technical team works alongside your regulatory department to streamline product approvals, whether with the FDA, EFSA, or local health ministries.
China is home to over 70% of the world's Ginkgo biloba forests. Our extraction facility is strategically situated near major cultivation belts, guaranteeing a steady supply of fresh leaves. Combining this geography with our high-volume extraction capabilities, automated solvent recovery systems, and efficient supply networks, we offer stable pricing and prompt delivery even during market fluctuations.
The global dietary supplement industry is shifting rapidly toward clean-label, low-residue ingredients. Modern buyers demand zero-residue solvents and complete traceability. Our specialized acetone-water extraction process effectively isolates targeted therapeutic compounds while keeping alkylphenols below 1 ppm, perfectly aligning with these clean-label market expectations.
Standardized Ginkgo Biloba Extract EGb 761 is highly versatile and used across multiple product formulations:
Answering key technical, safety, and logistical questions from procurement managers and formulation chemists.
EGb 761 is a highly specific, clinically studied pharmaceutical-grade extract standardized to 24% flavone glycosides and 6% terpene lactones. It must follow a precise extraction protocol that keeps cytotoxic alkylphenols (ginkgolic acids) under 5 ppm (and below 1 ppm in our premium batches). Generic extracts often fail to meet these narrow standard ranges or display the required proportions of bilobalide and ginkgolides A, B, and C.
The acetone-water extraction process is uniquely effective at isolating the active terpene lactones and flavone glycosides while leaving behind unwanted fats, waxes, and toxic ginkgolic acids. The European Pharmacopoeia and USP monographs for standardized EGb 761 are based on this acetone extraction process. UniCare operates the only EU-GMP compliant acetone-water extraction line in China, ensuring authentic compliance.
Adulteration with free kaempferol, quercetin, or rutin is a common issue in lower-grade extracts to falsely boost HPLC test results. Our CNAS-certified laboratory checks the ratios of kaempferol to quercetin and isorhamnetin to quercetin. If these ratios fall outside the established natural botanical fingerprint, the batch is rejected. We also use TLC comparison and DNA barcoding to confirm raw leaf authenticity.
We provide comprehensive regulatory documentation to support international registration, including DMF (Drug Master File) filings, CEP (Certificate of Suitability), EU-GMP certificates, stability testing reports (conducted under ICH guidelines), allergen statements, GMO-free certifications, and Kosher/Halal approvals.
When stored in its original double-layered polyethylene bags inside airtight fiber drums, stored in a cool, dry place away from direct sunlight, our Ginkgo Extract EGb 761 has a validated shelf life of 36 months. We perform ongoing stability testing under controlled temperature and humidity conditions to verify long-term assay stability.
Yes, we can customize particle sizes (mesh size) and bulk density to match your manufacturing process, whether for direct-compression tablets or capsule filling. We can also modify the carrier options or active concentration profiles to meet your specific formulation requirements.
Complete your sourcing portfolio with our highly standardized, certified active botanical ingredients.
