Explore our premium grade active ingredients manufactured at our GMP certified facilities, engineered for pharmaceutical, cosmetic, and nutraceutical formulations.
Polyphenols represent a diverse class of naturally occurring organic compounds characterized by the presence of multiple phenol units. These secondary metabolites are synthesized by plants as defense mechanisms against ultraviolet radiation, pathogenic attacks, and ecological oxidative stresses. Structurally, their antioxidant potency depends heavily on the spatial configuration of hydroxyl groups attached to the aromatic benzene rings, allowing them to effectively neutralize reactive oxygen species (ROS) through radical scavenging and metal chelation.
In industrial applications, polyphenols are categorized into four primary groups: flavonoids (such as Quercetin, icariin from Epimedium, and Rutin), phenolic acids, polyphenolic amides, and other non-flavonoid polyphenols like Resveratrol. Understanding their distinct chemical profiles is essential for formulators seeking targeted metabolic benefits in functional foods, dietary supplements, and dermo-cosmetic therapies.
How international regulatory pathways, localization, and regional market preferences shape the procurement of premium plant-based active ingredients.
B2B buyers face distinct regional regulatory landscapes. While the North American market relies on FDA dietary supplement frameworks (NDI, GRAS), European markets face stringent EFSA novel food evaluations. Our compliance team ensures raw materials conform to the Pharmacopoeia standards of key markets, including USP, EP, and ChP.
The demand for active molecules shifts by market. East Asia leads in using polyphenols like Green Tea Extract and Olive Leaf Extract for advanced topical skincare and whitening agents. Conversely, Western formulation trends prioritize cardio-metabolic support, incorporating Berberine HCl and high-potency Milk Thistle.
Unmodified polyphenols often suffer from poor water solubility and rapid hepatic clearance. To resolve these challenges, our R&D center optimizes particle size distribution and supplies micronized powders, liposomal complexes, and water-soluble alternatives to maximize target absorption and product shelf life.
UniCare is a professional supplier of natural active ingredients. Our products are widely used in various fields such as dietary supplement, food, cosmetics and pharmaceuticals. We focus on product development and quality stability, and insist on growing together with our customers around the world.
UniCare has deep cooperation with several excellent Chinese manufacturers who have complete quality management system certifications, including but not limited to GMP, EUGMP, CEP, ISO9001, ISO22000, and HACCP. Each factory has independent testing capabilities and is equipped with advanced and efficient testing equipment to ensure the high quality and long-term stability of each batch of products.
Contact UsGuiding principles that drive our innovation, quality control, community responsibility, and technological development.
UniCare operates the largest and most technologically advanced extraction facility in China, integrating automated controls with strict international GMP protocols.
UniCare attaches great importance to the hardware conditions of production equipment and has the largest and most advanced extraction factory in China. The entire production line in UniCare is controlled by a modern, intelligent, automatic control system.
Until now, UniCare has built up two GMP workshops, containing six multi-functional extraction lines, among which there is the only production line for Ginkgo Biloba Extract of acetone process in the whole China. Here are several other production lines including fermentation production lines and Chinese medicine pieces. A total of 30,000 tons of various Chinese medicine plant raw materials can be processed each year.
Our main extraction facilities comply strictly with China’s Good Manufacturing Practices standards.
We hold EU-GMP and CEP certifications for our highly demanded Ginkgo Biloba Extract.
All manufacturing and extraction lines employ real-time DCS automation system control.
Equipped with high-performance continuous countercurrent and loop extraction columns.
Capable of processing up to 30,000 tons of raw herbal material to guarantee continuous supply.
Equipped with multiple annular dynamic countercurrent and multi-functional extraction tanks.
The only facility in China configured for acetone-based extraction meeting European Pharmacopoeia (EP) guidelines.
Features six 20-ton fermentation tanks to enable high-efficiency enzyme-modified natural compounds.
A deep dive into our systematic technical approach to natural active ingredient processing, from raw botanicals to highly bioavailable standardized powders.
Standardization begins at the planting base. Utilizing hybridized seedlings and GACP cultivation, we systematically maximize the baseline concentration of primary polyphenols in raw leaves, bark, or roots before harvesting.
Employing low-temperature, pressurized dynamic countercurrent systems prevents thermal degradation of fragile polyphenolic polymers, yielding up to 25% higher active extraction density compared to static batch systems.
Crude extracts run through adsorption columns packed with customized macroporous resin beads. This system isolates targeted active components and scrubs heavy metals, starches, and inorganic salts.
Through structural biological modifications via industrial fermentation, we convert complex glycosides into smaller aglycones, dramatically improving solubility profiles and physiological bioavailability.
Using low-temperature concentration membranes followed by automated spray drying, we achieve exceptionally consistent particle sizes, optimizing flowability and preventing clumping during tablet or capsule manufacturing.
Our future technical focus integrates liposomal and cyclodextrin complexation. Shielding active molecules ensures stability during passage through gastric acid, delivering targeted release in the gut.
United New Life (UniCare) has established a leading and complete quality control system, and strictly controls the high quality of products in accordance with the quality system.
With advanced testing instruments, strict control of product quality, to provide every customer with high quality products. Detectable items are: Signature component detection (HPLC or UV), solvent residues GC, pesticide residues (organochlorine detection) GC-MS-MS, heavy metals (lead, arsenic, mercury, cadmium, copper) ICP-MS microscopic identification, moisture, dry weight loss, ash, microbial limits, thin layer identification, weighing, conductivity, PH, sulfur dioxide residue, routine detection, etc.
Important testing instruments are: Two UHPLC Agilent 1290 ultra-high performance liquid chromatographs, four HPLC Agilent 1260 high performance liquid chromatography sets, two HPLC Shimadzu LC-20AT high performance liquid chromatographs, two HPLC Dionex (Diane) CU3000, two Shimadzu evaporative light scattering detectors (ELSD) 2000ES, one Shimadzu GC2010 gas chromatograph, and one Shimadzu AA-7000 atomic absorption system.
| Analytical Category | Specific Detection Parameters |
|---|---|
| Active Ingredient Analysis | Assay, chemical fingerprinting, HPLC/UV verification, identification |
| Hazardous Substance Analysis | Heavy metals (ICP-MS), pesticide residue (GC-MS-MS), solvent residue (GC-headspace) |
| Microbe Analysis | Total aerobic microbial count (TAMC), Escherichia coli, Yeast & mould, specific pathogen testing |
| Raw Material Control | Pesticide residue tracing, allergen declaration, Non-GMO verification, botanical origin authentication |
| Laws & Regulations Confirmation | Compliance matching for China, US FDA, EU EFSA, and target export destinations |
| Stability Test | Accelerated and long-term shelf-life validation according to ICH guidelines |
| Others | pH value, moisture, ash, optical rotation, particle size distribution, bulk density |
| Instrument Class | Manufacturer & Model | Quantity |
|---|---|---|
| UHPLC (Ultra-High Performance Liquid Chromatograph) | Agilent 1290 Series | 2 Units |
| HPLC (High Performance Liquid Chromatograph) | Agilent 1260 Series | 4 Units |
| HPLC (High Performance Liquid Chromatograph) | Shimadzu LC-20AT Series | 2 Units |
| HPLC (High Performance Liquid Chromatograph) | Dionex CU3000 Series | 2 Units |
| ELSD (Evaporative Light Scattering Detector) | Shimadzu 2000ES Series | 2 Units |
| GC (Gas Chromatograph) | Shimadzu GC-2010 Series | 1 Unit |
| AAS (Atomic Absorption Spectrophotometer) | Shimadzu AA-7000 Series | 1 Unit |
Our analytical laboratory covers a large footprint and is fully qualified by CNAS, ensuring that all certificates of analysis (COA) are universally accepted for global customs clearance and quality release.
Combining academic research partnerships with vertically integrated botanical cultivation to yield consistent active contents and optimized pricing.
UniCare invests 10% of our annual net profit in research and development. In addition to optimizing and developing the existing natural plant extraction process, we have also established a professional R&D department for the natural fermentation products. By increasing investment in natural fermentation products, we try to break through the traditional processes and disrupt industry development.
UniCare has deep cooperation with Beijing University of Chemical Technology in the field of fermentation, jointly developing and transforming the new raw materials of pharmaceutical, cosmetic, and natural health products into mass-produced products.
In order to control raw materials more efficiently and with higher quality, a raw material procurement system has been established, which extends procurement to every piece of planting land and can trace the raw materials of each batch of products. The storage of raw materials is operated according to the advanced quality management system process, and the content of active ingredients, moisture, ash, heavy metals, pesticide residues and other items of raw materials are strictly controlled.
At the same time, in order to further ensure the high quality of important products, UniCare cooperated with planting farmers to establish ginkgo leaf planting bases, epimedium planting bases, phellodendron planting bases, olive leaf planting bases, etc. Some of these bases are planted strictly in accordance with the GACP management model. In addition, we cooperate with seedling research and development companies to develop high-content seedling cultivation, and cultivate better seedlings through hybridization or gene optimization, so as to continuously reduce unit costs to benefit users.
A visual walk-through of UniCare's industrial footprint, showing our GMP-compliant workshop clean rooms, advanced reaction columns, and bulk warehousing.
Providing seamless validation, registration documentation, and batch consistency to simplify B2B customs and regulatory compliance.
We prepare comprehensive dossier documentation for New Dietary Ingredients (NDI) submissions and Self-Affirmed GRAS validation. Our facilities are registered with the US FDA, and we offer FSMA-compliant supply chain certificates.
For export to European markets, our plant extracts comply with strict limits on polycyclic aromatic hydrocarbons (PAHs), ethylene oxide (EtO) residues, and pyrrolizidine alkaloids. Active substances are mapped to CEP requirements.
We support registration for Chinese blue-hat health foods, Japanese functional claims (FOSHU), and Australian TGA standards, supplying detailed stability data and chemical fingerprints (HPLC chromatograms).
Critical, high-intent technical questions asked by global formulation scientists and B2B raw material procurement managers.
Our extraction systems use food-grade ethanol-water mixtures, pure water, or, in the case of our CEP-certified Ginkgo Biloba line, an acetone-water process. Solvent recovery towers ensure residual levels remain well below USP/EP guidelines, verified via headspace gas chromatography (GC).
We mitigate raw variance in active markers through two key measures: first, by sourcing raw botanical inputs directly from GACP-managed cooperative planting bases; second, by utilizing real-time inline HPLC controls and precise blending parameters during final batch processing to keep standard deviations within ±2%.
Thermal degradation is prevented by using low-temperature vacuum concentration and rapid, low-residence-time spray dryers. Additionally, the introduction of inert nitrogen blankets within our storage silos prevents oxidation during intermediate production phases.
Yes. Our finishing workshops are equipped with air-jet micronization mills capable of customizing particle size profiles. We can supply standard 80-mesh powders as well as micro-powders exceeding 200-mesh, optimizing dissolution speeds and flowability for tableting.
Every single batch undergoes validation in our CNAS-qualified laboratory. We test for heavy metals (Lead, Arsenic, Cadmium, Mercury) using high-precision Agilent ICP-MS systems, and we run multi-residue pesticide screens using GC-MS-MS to guarantee compliance with EU Regulation 396/2005 and USP <561>.
Explore our premium grade active ingredients manufactured at our GMP certified facilities, engineered for pharmaceutical, cosmetic, and nutraceutical formulations.
