In the rapidly evolving landscape of metabolic health, traditional supplements are undergoing a profound paradigm shift driven by pharmacological efficacy. At the forefront of this shift is the transition from standard Berberine HCl to its highly bioavailable hydrogenated derivative: Dihydroberberine (DHB), widely known in commercial sectors under the brand optimization of GlucoVantage®. Standard berberine has historically faced significant challenges regarding bioavailability, intestinal absorption, and gastrointestinal distress, primarily due to the body's rate-limiting metabolic pathways.
When ingested, standard Berberine HCl requires reduction by the gut microbiota into its active dihydro form before it can be effectively absorbed through the intestinal epithelium. By delivering Dihydroberberine directly, modern formulations bypass this rate-limiting reduction step. Peer-reviewed pharmacokinetic studies indicate that Dihydroberberine exhibits up to 5x the bio-absorption rate of traditional berberine, allowing for much lower dosages (e.g., 100mg to 200mg of DHB compared to 500mg to 1500mg of standard Berberine) while significantly mitigating typical gastrointestinal side effects such as cramping and diarrhea.
As a leading hub for phytochemistry and industrial synthesis, China's modern botanical manufacturing ecosystem has established robust pathways to produce high-purity Dihydroberberine, allowing international dietary brand owners to achieve unprecedented cost efficiencies and product efficacy.
Leveraging decades of phytochemistry experience, modern infrastructure, and fully integrated supply chains to provide world-class active pharmaceutical and health ingredients.
Our extraction lines adopt modern, intelligent, and automated control systems, maximizing batch-to-batch consistency and minimizing anthropogenic contamination risks.
With processing capabilities of up to 30,000 tons of botanical raw materials per year, our scaling efficiency keeps raw input costs highly competitive for global distribution networks.
Our production facilities adhere strictly to China-GMP regulations, with specialized lines complying with EU-GMP and CEP requirements to guarantee acceptance in highly regulated markets.
UniCare is a professional supplier of natural active ingredients. Our products are widely used in various fields such as dietary supplement, food, cosmetics and pharmaceuticals. We focus on product development and quality stability, and insist on growing together with our customers around the world.
UniCare has deep cooperation with several excellent Chinese manufacturers who have complete quality management system certifications, including but not limited to GMP, EUGMP, CEP, ISO9001, ISO22000, and HACCP. Each factory has independent testing capabilities and is equipped with advanced and efficient testing equipment to ensure the high quality and long-term stability of each batch of products.
Unearthing and developing the latent therapeutic values of historical herbal medicine through scientific optimization.
Continuous investment in process optimization, biological fermentation, and state-of-the-art separations.
Deploying the industry's most advanced chemical engineering parameters to assure standard-setting quality.
Ensuring our staff thrives in safe conditions while actively giving back to rural planting communities.
UniCare attaches great importance to the hardware conditions of production equipment and has the largest and most advanced extraction factory in China. The entire production line in UniCare is controlled by a modern, intelligent, automatic control system. Until now, UniCare has built up two GMP workshops, containing six multi-functional extraction lines, among which there is the only production line for Ginkgo Biloba Extract of acetone process in the whole China. Here are several other production lines including fermentation production lines and Chinese medicine pieces. A total of 30,000 tons of various Chinese medicine plant raw materials can be processed each year.
All chemical processes, materials storage, and purification steps are strictly aligned with national pharmaceutical safety controls.
Our leading Ginkgo Biloba extraction setup meets the absolute gold standard for European imports and monograph compliance.
SCADA and PLC interfaces govern flow rates, temperatures, and pressure levels across all critical plant extraction steps.
Featuring the latest countercurrent reactors to maximize active molecule retrieval and yield percentages.
Massive throughput pipelines ensure we remain a highly stable supplier for high-volume contract manufacturers globally.
Comprising three dynamic countercurrent arrays (10t & 15t), two multi-functional tank networks (32 tanks total), and circular reactors.
Houses the only EU-GMP conforming acetone extraction pipeline for Ginkgo Biloba in the region.
Six 20-ton fermentation tanks optimized for enzyme-modified bio-transformations and metabolic intermediates.
United New Life (UniCare) has established a leading and complete quality control system, and strictly controls the high quality of products in accordance with the quality system. With advanced testing instruments, strict control of product quality, to provide every customer with high quality products.
Detectable items include: Signature component detection (HPLC or UV), solvent residues GC, pesticide residues (organochlorine detection) GC-MS-MS, heavy metals (lead, arsenic, mercury, cadmium, copper) ICP-MS microscopic identification, moisture, dry weight loss, ash, microbial limits, thin layer identification, weighing, conductivity, pH, sulfur dioxide residue, routine detection, etc.
| Quality Control Categories | Testing Items & Parameter Limits |
|---|---|
| Active Ingredient Analysis | Quantitative Assay, Chromatographic identification, High Performance Liquid Chromatography (HPLC) profiles |
| Hazardous Substance Analysis | Heavy metals (ICP-MS), Pesticide residues screening (GC-MS-MS), Residual solvent analysis (GC Headspace) |
| Microbe Analysis | Total Aerobic Microbial Count (TAMC), Yeast & mould count (TYMC), Escherichia coli, Salmonella, specific pathogens tests |
| Raw Material Control | GACP planting origin check, GMO status validation, Allergen screening, Pesticide limits validation at farm level |
| Laws & Regulations | Compliance investigation relative to EU monographs, US FDA regulations, USP standards, and China GB food codes |
| Stability Test | Accelerated and real-time stability testing to define and guarantee precise expiration date profiles |
| Physical/Chemical Properties | pH value, Moisture Content, Total Ash, Tap/Bulk density, Mesh Particle size analysis, Optical rotation |
To support high-purity research like Dihydroberberine synthesis validation, our Central Lab is equipped with cutting-edge analytical hardware:
UniCare invests 10% of our annual net profit in research and development. In addition to optimizing and developing the existing natural plant extraction process, we have also established a professional R&D department for the natural fermentation products. By increasing investment in natural fermentation products, we try to break through the traditional processes and disrupt industry development.
UniCare has deep cooperation with Beijing University of Chemical Technology in the field of fermentation, jointly developing and transforming the new raw materials of pharmaceutical, cosmetic, and natural health products into mass-produced products.
In order to control raw materials more efficiently and with higher quality, a raw material procurement system has been established, which extends procurement to every piece of planting land and can trace the raw materials of each batch of products. The storage of raw materials is operated according to the advanced quality management system process, and the content of active ingredients, moisture, ash, heavy metals, pesticide residues and other items of raw materials are strictly controlled.
At the same time, in order to further ensure the high quality of important products, UniCare cooperated with planting farmers to establish ginkgo leaf planting bases, epimedium planting bases, phellodendron planting bases, olive leaf planting bases, etc. Some of these bases are planted strictly in accordance with the GACP management model.
Global brands are optimizing Dihydroberberine by blending it with Quercetin to enhance absorption kinetics, or combining it with Ginkgo Biloba Extract to offer integrated cognitive-metabolic protection formulas.
Targeting the rising demand for anti-aging supplements, our industrial Dihydroberberine acts as a direct AMPK activator, offering a clean, non-prescription alternative to traditional glucose-stabilizing molecules.
Through our GACP-certified Phellodendron and alternative Berberis planting bases, we guarantee a secure, deforestation-free botanical pipeline that satisfies rigorous EU Deforestation Regulations (EUDR).
