Explore our primary portfolio of high-purity natural extracts optimized for pharmaceutical, nutraceutical, and clinical formulations.
Berberine, a quaternary ammonium alkaloid extracted from plants such as Berberis aristata and Phellodendron amurense, has emerged as a cornerstone compound in the global metabolic health market. As cardiovascular disorders, insulin resistance, and metabolic syndrome rise globally, international pharmaceutical and dietary supplement brands are prioritizing secure supply chains of high-purity Berberine Hydrochloride (HCl).
Our market research shows that the global demand for Berberine is growing at a CAGR of over 8.5%. B2B buyers face challenges with batch-to-batch variation, residual solvents, heavy metal contamination, and low raw material traceability. As a leading manufacturer and exporter in China, UniCare addresses these core problems by combining standardized industrial cultivation with strict quality management systems.
We manufacture tailored specifications to match different regional pharmacopoeias and custom formulations:
| Purity (HPLC) | ≥ 97.0%, ≥ 98.0% (Berberine HCl) |
| Appearance | Yellow Crystalline Powder |
| Standard Grades | USP / EP / BP / CP compliant |
| Solvents Residual | Ethanol only (Methanol/Isopropanol Free) |
| Mesh Size | 80 Mesh, 100 Mesh (Customizable micronization) |
How we optimize extraction technology, reduce environmental impact, and improve bioavailability.
We work with breeding research partners to develop high-yield crop varieties via hybridization and gene optimization. This increases the baseline concentration of berberine in roots and bark, reducing raw material costs and land requirements.
Traditional static soaking has been replaced by dynamic countercurrent systems. By optimizing flow rates, extraction temperature, and solid-to-liquid ratios, we maximize compound recovery while cutting solvent use by 40%.
Natural berberine exhibits low oral bioavailability. We are researching and developing sustained-release formulations, liposomal delivery systems, and organic micro-encapsulation to improve intestinal absorption rates.
A professional supplier of natural active ingredients, focusing on development, quality stability, and shared growth with global partners.
UniCare has deep cooperation with several excellent Chinese manufacturers who have complete quality management system certifications, including but not limited to GMP, EUGMP, CEP, ISO9001, ISO22000, and HACCP. Each factory has independent testing capabilities and is equipped with advanced and efficient testing equipment to ensure the high quality and long-term stability of each batch of products.
UniCare prioritizes high-grade production hardware, operating the largest and most advanced plant extraction facilities in China.
UniCare's integrated plant extraction workshops operate under cleanroom protocols to prevent cross-contamination.
Our extraction line is controlled by a modern, intelligent, automatic control system. UniCare operates two GMP workshops, containing six multi-functional extraction lines, including the only production line for Ginkgo Biloba Extract using an acetone process in China. These facilities support our global raw material processing and extraction operations.
Discover and create new value from natural herbs to support human health.
Commit to ongoing R&D processes, upgrading extraction technology and purification pathways.
Utilize modern instrumentation to manufacture high-quality, standardized products.
Foster employee development and contribute to sustainable agricultural communities.
UniCare operates a comprehensive quality control system, monitoring all manufacturing stages in accordance with international standards.
Using advanced analytical instruments, we test and verify raw materials and finished products to ensure high safety and efficacy. Our standard testing protocols cover active ingredient assays (via HPLC or UV), GC analysis for residual solvents, GC-MS-MS for pesticide residues (organochlorine testing), ICP-MS for heavy metals (lead, arsenic, mercury, cadmium, copper), along with microscopic identification, moisture, loss on drying, ash content, microbial limits, TLC identification, particle size, pH, and sulfur dioxide residues.
| Testing Domain | Specific Parameters & Analytical Methods |
|---|---|
| Active Ingredient Analysis | Assay testing, identification, chemical profiling. |
| Hazardous Substance Analysis | Heavy metals quantification, pesticide residue screening, residual solvents testing. |
| Microbial Analysis | Total plate count, Escherichia coli, Yeast & mold, and specific pathogen testing. |
| Raw Material Control | Pesticide residues, allergen screening, GMO testing, botanical origin verification. |
| Regulatory Compliance | Continuous alignment with Chinese and international pharmaceutical/food regulations. |
| Stability Studies | Shelf-life verification under accelerated and long-term stability conditions. |
| Physical/Chemical Properties | pH value, moisture, ash content, optical rotation, particle size distribution, bulk density, etc. |
Our Central Lab is qualified by CNAS and equipped with high-precision analytical equipment, including:
| Equipment Type | Manufacturer & Specification | Quantity |
|---|---|---|
| UHPLC | Agilent 1290 (Ultra-High Performance Liquid Chromatography) | 2 Units |
| HPLC | Agilent 1260 / Shimadzu LC-20AT / Dionex Ultimate 3000 | 8 Units |
| ELSD | Shimadzu 2000ES (Evaporative Light Scattering Detector) | 2 Units |
| GC | Shimadzu GC-2010 (Gas Chromatograph) | 1 Unit |
| AAS | Shimadzu AA-7000 (Atomic Absorption Spectrophotometer) | 1 Unit |
Controlling quality from seed selection to advanced enzymatic fermentation processes.
UniCare invests 10% of our annual net profit in research and development. In addition to optimizing traditional plant extraction, we have established a dedicated R&D department for natural fermentation. We aim to break through traditional extraction limits by introducing biological fermentation techniques.
We work in close cooperation with the Beijing University of Chemical Technology in the field of fermentation, co-developing and scaling up new active ingredients for the pharmaceutical, cosmetic, and nutraceutical industries.
To improve quality control, we operate a fully traceable procurement system that monitors raw materials down to the individual planting plot. Sourced materials are processed under our advanced quality management system, with strict testing for active ingredient concentrations, moisture, ash, heavy metals, and pesticide residues.
UniCare partners with local growers to establish dedicated cultivation bases, including Ginkgo leaf, Epimedium, Phellodendron, and Olive leaf planting bases. Selected sites are managed in strict compliance with GACP guidelines. We also collaborate with seedling development firms to select high-yield crop variants through natural hybridization and genetic optimization, helping lower overall manufacturing costs.
How global manufacturing sectors utilize our high-purity Berberine Hydrochloride.
Commonly formulated into tablets, capsules, and softgels targeting blood sugar management and cardiovascular health. Manufacturers frequently pair it with Chromium Picolinate, Alpha-Lipoic Acid, or Silymarin to enhance therapeutic outcomes.
Utilized as an active pharmaceutical ingredient (API) or intermediate for GI treatments and anti-pathogenic formulations. Our strict USP/EP monograph compliance ensures smooth regulatory filings.
Due to its anti-inflammatory, sebum-regulating, and antimicrobial properties, bio-purified berberine is increasingly formulated into topical products for acne-prone and sensitive skin.
Technical answers to help buyers evaluate quality, regulatory compliance, and formulation stability.
We extract our Berberine Hydrochloride primarily from Phellodendron amurense (Amur Cork Tree bark) and Berberis aristata. The selection is determined by our clients' custom specifications and the target regulatory markets (e.g., USP vs. EP standards).
We monitor contaminants in our raw materials and finished batches. Heavy metals are quantified using ICP-MS, keeping Lead (Pb) < 0.5 ppm, Arsenic (As) < 0.5 ppm, Cadmium (Cd) < 0.1 ppm, and Mercury (Hg) < 0.1 ppm. Pesticide residues are analyzed using GC-MS-MS to meet EP 2.8.13 and USP <561> limits.
Our extraction process uses food-grade ethanol and purified water. We do not use toxic Class 1 or Class 2 solvents like methanol, benzene, or chlorinated hydrocarbons. Residual ethanol is kept well below USP/ICH limits (< 5000 ppm) through vacuum drying.
Yes, we offer custom milling. Our standard powder is 80 mesh, but we can supply micronized versions (e.g., 100 mesh or 200 mesh) to fit different capsule filling or direct compression tableting setups.
Every batch is shipped with a comprehensive Certificate of Analysis (COA), documenting HPLC assay values, moisture, ash, heavy metals, microbial limits, and residual solvent levels. Upon request, we also provide MSDS, GMO-free statements, Allergen statements, and process flowcharts.
High-purity botanical raw materials manufactured under GMP guidelines and validated by our CNAS-certified laboratory.
