Explore our primary, certified extract ranges optimized for regulatory compliance and stable commercial supply chains globally.
In the rapidly expanding market of functional foods, nutraceuticals, and preventive clinical medicine, yeast beta-glucan (specifically derived from the cell walls of Saccharomyces cerevisiae) has emerged as one of the most rigorously researched biological response modifiers. Known commercially under premium brands such as Yestimun®, this specific structural configuration of beta-1,3/1,6-D-glucan plays an essential role in priming the innate immune system. As a leading manufacturer and exporter, UniCare bridges the gap between high-yield, premium-quality Chinese manufacturing bases and global brands looking for stable, pure, and compliant active ingredients.
Our enterprise acts as a high-capacity gateway for sourcing, auditing, and supplying premium natural active ingredients. Backed by rigorous quality control protocols and certified manufacturing facilities, we ensure that batch-to-batch consistency matches the exact requirements of pharmaceutical and dietary supplement formulations in North America, Europe, and Asia-Pacific regions.
The international demand for Yeast Beta-Glucan is undergoing a significant transition. Historically, immune support ingredients were dominated by vitamin C, zinc, and botanicals such as Echinacea. However, current clinical literature demonstrates that yeast-derived beta-glucans offer a superior mechanism of action. By binding to the dectin-1 receptors on macrophages and neutrophils, beta-1,3/1,6-D-glucan "primes" these defense cells without overstimulating the immune system or triggering harmful inflammatory cascades.
Global consumers demand transparent labels. Yeast beta-glucan extracted via chemical-free processes from non-GMO yeast strains fits the natural formulation trends preferred by modern retail brands.
Beta-glucans are increasingly combined with probiotics, postbiotics, and plant adaptogens to create multi-functional formulations addressing gut health, stress, and immune support simultaneously.
To mitigate geopolitical risk and freight volatility, global enterprises require suppliers who have large production scales, pre-audited compliance protocols, and decentralized logistics pathways.
UniCare is a professional supplier of natural active ingredients. Our products are widely used in various fields such as dietary supplement, food, cosmetics and pharmaceuticals. We focus on product development and quality stability, and insist on growing together with our customers around the world.
UniCare has deep cooperation with several excellent Chinese manufacturers who have complete quality management system certifications, including but not limited to GMP, EUGMP, CEP, ISO9001, ISO22000, and HACCP. Each factory has independent testing capabilities and is equipped with advanced and efficient testing equipment to ensure the high quality and long-term stability of each batch of products.
We combine historical herbal knowledge with modern extraction technology to maximize bioavailability and stability.
Constantly refining manufacturing yield, reducing solvent use, and optimizing purification columns for eco-friendly operations.
Deploying state-of-the-art instrumentation to satisfy the most stringent international monograph criteria.
Promoting corporate social responsibility, fair trade sourcing models, and maintaining safe working environments.
UniCare attaches great importance to the hardware conditions of production equipment and has the largest and most advanced extraction factory in China. The entire production line in UniCare is controlled by a modern, intelligent, automatic control system. Until now, UniCare has built up two GMP workshops, containing six multi-functional extraction lines, among which there is the only production line for Ginkgo Biloba Extract of acetone process in the whole China. Here are several other production lines including fermentation production lines and Chinese medicine pieces. A total of 30,000 tons of various Chinese medicine plant raw materials can be processed each year.
China GMP compliance: The factory has passed the official China GMP certification, meeting high pharmaceutical standards.
EUGMP & CEP Certification: The EU-GMP and CEP of Ginkgo Biloba Extract has been certified, proving international viability.
Automated Control: All extraction production lines adopt modern, intelligent, and automated control systems for precision.
High-End Hardware: Own the most advanced extraction and molecular separation equipment available in China.
High Raw Material Sourcing: Annual processing of 30,000 tons of Chinese medicine and plant raw materials.
Six Industrial Lines: Three annular dynamic countercurrent extraction lines (10T & 15T); two multi-functional lines (32 tanks, 6m³ each); one round dynamic line (10T).
Specialty Acetone Extraction: Own the only acetone process extraction line for Ginkgo Biloba Extract in China that meets the EU GMP standards.
Bioprocess Fermentation: Own six fermentation tanks (20 tons capacity each) for the production of enzyme-modified products.
United New Life has established a leading and complete quality control system, and strictly controls the high quality of products in accordance with the quality system. With advanced testing instruments and strict control of product quality, we provide every customer with high quality products.
Detectable items include: Signature component detection (HPLC or UV), solvent residues GC, pesticide residues (organochlorine detection) GC-MS-MS, heavy metals (lead, arsenic, mercury, cadmium, copper) ICP-MS microscopic identification, moisture, dry weight loss, ash, microbial limits, thin layer identification, weighing, conductivity, pH, sulfur dioxide residue, routine detection, etc.
Important testing instruments deployed: Two UHPLC Agilent 1290 ultra-high performance liquid chromatographs, four HPLC Agilent 1260 high performance liquid chromatography sets, two HPLC Shimadzu LC-20AT high performance liquid chromatographs, two HPLC Dionex UltiMate 3000, two Shimadzu evaporative light scattering detector 2000ES, one Shimadzu GC2010 gas chromatograph, and one Shimadzu AA-7000 atomic absorption system.
| Instrument Type | Manufacturer & Model | Quantity | Primary Analytical Function |
|---|---|---|---|
| UHPLC | Agilent 1290 | 2 | Ultra-high efficiency active ingredient assays, peak resolution |
| HPLC | Agilent 1260 | 4 | Quantitative standardizations of organic marker substances |
| HPLC | Shimadzu LC-20AT | 2 | Routine assays & product stability screening |
| ELSD | Shimadzu 2000ES | 2 | Detection of non-UV absorbing lipid/carbohydrate compounds |
| GC | Shimadzu GC-2010 | 1 | Organic residual solvents determination (class 1, 2, 3 solvents) |
| AAS | Shimadzu AA-700 | 1 | Heavy metal tracing (Pb, Cd, As, Hg) to USP/EP thresholds |
| Audit Dimension | Detailed Testing Parameters & Methodology |
|---|---|
| Active Ingredient Analysis | Assay, absolute identification, HPLC/UV fingerprints, carbohydrate sizing. |
| Hazardous Substance Analysis | Heavy metal testing, organic pesticide residues (GC-MS-MS), residual solvent control. |
| Microbe Analysis | Total plate count, E. coli, Yeast & mould, absence of pathogens (Salmonella, Staphylococcus). |
| Raw Material Control | Pesticide profiling, allergen tracking, non-GMO status, geographic botanical source verification. |
| Laws & Regulations | Compliance checking against CFDA, FDA, EFSA, USP, EP, and local market monographs. |
| Stability Testing | Accelerated and long-term climate chamber shelf life studies. |
| Physical Characteristics | pH value, moisture, ash, optical rotation, bulk density, particle size mesh profile. |
Our central lab is fully equipped and qualified by CNAS, operating under strict international calibration and testing standards.
UniCare invests 10% of our annual net profit in research and development. In addition to optimizing and developing the existing natural plant extraction process, we have also established a professional R&D department for natural fermentation products. By increasing investment in natural fermentation products, we try to break through traditional processes and drive industry progress.
UniCare has deep cooperation with Beijing University of Chemical Technology in the field of fermentation, jointly developing and transforming new raw materials of pharmaceutical, cosmetic, and natural health products into mass-produced products.
In order to control raw materials more efficiently and with higher quality, a raw material procurement system has been established, which extends procurement to every piece of planting land and can trace the raw materials of each batch of products. The storage of raw materials is operated according to the advanced quality management system process, and the content of active ingredients, moisture, ash, heavy metals, pesticide residues and other items of raw materials are strictly controlled.
At the same time, in order to further ensure the high quality of important products, UniCare cooperated with planting farmers to establish ginkgo leaf planting bases, epimedium planting bases, phellodendron planting bases, olive leaf planting bases, etc. Some of these bases are planted strictly in accordance with the GACP management model. In addition, we cooperate with seedling research and development companies to develop high-content seedling cultivation, and cultivate better seedlings through hybridization or gene optimization, so as to continuously reduce unit costs to benefit users.
For formulators looking to understand the technical specifications, Yestimun® Yeast Beta-Glucan is characterized by its high structural purity and concentration. While oat, barley, and mushroom beta-glucans exist with 1,3/1,4 link patterns or complex chitin bindings, yeast-derived glucans boast a robust skeleton of beta-1,3-glucan with regular, short branches of beta-1,6-glucan.
This specific steric structure matches mammalian immune receptor sites. Because the raw material is derived from brewer's yeast cell walls, it has a higher branching frequency compared to baker's yeast, leading to stronger immune receptor recognition. Our extraction and isolation processes yield a fine, free-flowing powder with excellent dispersion, suitable for hard capsules, tablets, sachets, functional dairy, and cosmetic emulsions.
| Specification Parameter | Standard Target Limits | Analytical Method Reference |
|---|---|---|
| Appearance | Off-white to light beige fine powder | Visual Organoleptic |
| Assay (Beta-1,3/1,6-D-Glucan) | ≥ 85.0% (on dry basis) | Enzymatic / Gravimetric (Megazyme method) |
| Loss on Drying | ≤ 6.0% | USP <731> (105°C, 3 hours) |
| Total Ash | ≤ 3.0% | USP <561> |
| Heavy Metals (Pb) | ≤ 1.0 ppm | ICP-MS (USP <233>) |
| Arsenic (As) | ≤ 0.5 ppm | ICP-MS (USP <233>) |
| Total Aerobic Plate Count | ≤ 1,000 cfu/g | USP <61> / FDA BAM |
| Pathogens | Negative in 25g (Salmonella, E. coli) | USP <62> |
Procurement directors in multinational health food brands face multiple risks when importing raw materials from China: quality fluctuations between batches, non-compliant export documentation, and shipping delays. UniCare addresses these pain points directly:
We provide comprehensive regulatory dossiers, including BSE/TSE-free certificates, allergen reports, GMO statements, flow charts, and detailed production logs, ensuring smooth local regulatory compliance.
Every export shipment can be validated by independent laboratories such as Eurofins, SGS, or Intertek, checking purity, pesticide levels, and heavy metals prior to port departure.
Our dedicated logistics department manages global shipping, customs brokerage, and documentation, ensuring seamless port entry across the EU, US, and APAC regions.
At UniCare, we continuously refine our biological manufacturing techniques. Our long-term technical roadmap is focused on upgrading the bio-fermentation process. Through our partnership with the Beijing University of Chemical Technology, we are developing targeted enzymatic hydrolysis methods to produce water-soluble yeast beta-glucans.
By structurally altering the molecular weight distribution of beta-1,3/1,6-D-glucan without altering its immunomodulatory receptors, we aim to increase its solubility in liquid formulations. This will expand application possibilities from powder and capsule formulations to clear functional beverages, ready-to-drink functional shots, and dermatological cosmetics requiring high clarity and stability.
Review our full range of natural botanical extracts, manufactured in our high-capacity extraction plants in China.
