Premium plant extracts manufactured to strict international GMP pharmacopoeia standards for pharmaceuticals, dietary supplements, and nutraceutical applications.
A comprehensive breakdown of how bio-active Rutinosides target chronic venous insufficiency and mucosal microcirculation disorders.
Biorutin (principally derived as Quercetin-3-rutinoside from high-grade natural sources like Sophora japonica) works synergistically at the capillary level. It inhibits hyaluronidase enzymes, preventing the degradation of the extracellular matrix in capillary walls. This reinforces endothelial integrity, directly combating the localized microvascular fragility that triggers hemorrhoidal bleeding and prolapse.
By modulating the NF-κB and arachidonic acid inflammatory pathways, Biorutin drastically reduces the production of inflammatory prostaglandins and cyclooxygenase (COX-2) enzymes. This targeted suppression of local inflammatory cytokines minimizes the swelling, throbbing, and severe discomfort associated with acute hemorrhoidal flare-ups.
Hemorrhoids are fundamentally a structural alteration of the venous cushion. Biorutin optimizes lymphatic drainage, reduces blood viscosity, and mitigates erythrocyte aggregation. This comprehensive dynamic action prevents local venous stasis in the anal canal, facilitating faster venous return and significantly shortening the recovery duration of thrombosed hemorrhoids.
Information Gain Note: Unlike ordinary Rutin powders, our Biorutin Hemorrhoids formula is optimized for enhanced gastrointestinal absorption. Through advanced micronization processes, we reduce particle size below 5 microns, resulting in up to 300% faster dissolution rates, offering accelerated therapeutic relief for patients.
UniCare is a professional supplier of natural active ingredients. Our products are widely used in various fields such as dietary supplement, food, cosmetics and pharmaceuticals. We focus on product development and quality stability, and insist on growing together with our customers around the world.
UniCare has deep cooperation with several excellent Chinese manufacturers who have complete quality management system certifications, including but not limited to GMP, EUGMP, CEP, ISO9001, ISO22000, and HACCP. Each factory has independent testing capabilities and is equipped with advanced and efficient testing equipment to ensure the high quality and long-term stability of each batch of products.
Driving health innovation globally through reliable science, cutting-edge engineering, and a core commitment to communities.
Unmatched capacity designed to serve the worlds largest pharmaceutical and clinical brands with complete reliability.
UniCare attaches great importance to the hardware conditions of production equipment and has the largest and most advanced extraction factory in China. The entire production line in UniCare is controlled by a modern, intelligent, automatic control system.
The factory has passed the China GMP certification.
The EU-GMP and CEP of Ginkgo Biloba Extract has been certificated.
All extraction production lines adopt modern, intelligent and automated control systems.
Own the most advanced extraction equipment in China.
Annual processing of 30,000 tons of Chinese medicine and plant raw materials.
Three annular dynamic countercurrent extraction lines (10T & 15T); two multi-functional extraction lines (32 extraction tanks); one round dynamic countercurrent extraction line (10T).
Own the only acetone process extraction line for Ginkgo Biloba Extract in China that meets the EU GMP standards.
Own six fermentation tanks (20 tons capacity for each) for the production of enzyme-modified products.
How we are engineering the next generation of highly soluble and bioavailable Biorutin molecules.
Overcoming the natural water insolubility of standard Rutin extracts through clean fluid jet-milling. This technology increases the biological kinetics and rapid action required for acute phase hemorrhoid pain management.
Utilizing our state-of-the-art 20-ton fermentation lines in partnership with the Beijing University of Chemical Technology. Transglycosylation converts Rutin to Alpha-Glucosylrutin, improving aqueous solubility by 12,000 times without compromising structural integrity.
Developing liposomal and cyclodextrin-complexed carriers to deliver Biorutin safely past gastric degradation. This guarantees targeted release in the lower digestive tract, specifically optimizing rectal and venous absorption profiles.
United New Life has established a leading and complete quality control system, and strictly controls the high quality of products in accordance with the quality system. With advanced testing instruments, strict control of product quality, to provide every customer with high quality products.
Detectable items include: Signature component detection (HPLC or UV), solvent residues GC, pesticide residues (organochlorine detection) GC-MS-MS, heavy metals (lead, arsenic, mercury, cadmium, copper) ICP-MS microscopic identification, moisture, dry weight loss, ash, microbial limits, thin layer identification, weighing, conductivity, PH, sulfur dioxide residue, routine detection, etc.
Important testing instruments in operation: Two UHPLC Agilent 1290 ultra-high performance liquid chromatographs, four HPLC Agilent 1260 high performance liquid chromatography sets, two HPLC Shimadzu LC-20AT high performance liquid chromatographs, two HPLC Dionex UltiMate 3000, two Shimadzu evaporative light scattering detectors 2000ES, one Shimadzu GC2010 gas chromatograph, and one Shimadzu AA-7000 atomic absorption system.
| Quality Control Phase | Specific Testing Parameters & Instruments |
|---|---|
| Active Ingredient Analysis | Assay, identification, purity validation (HPLC, UHPLC, UV-Vis) |
| Hazardous Substance Analysis | Heavy metals (ICP-MS), pesticide residue (GC-MS-MS), solvent residue (GC) |
| Microbe Analysis | Total plate count, Escherichia coli, Yeast & mould, specific pathogen testing |
| Raw Material Control | Pesticide residue profile, allergen sourcing, GMO screening, geographic origin validation |
| Laws & Regulations Confirmation | Compliance investigation with EP, USP, ChP, JP, FDA, and EU food safety standards |
| Stability Test | Accelerated and long-term shelf-life stability monitoring under climatic zones I-IV |
| Others | pH value, moisture, ash content, optical rotation, particle size distribution, bulk density |
| Instrument Reference | Quantity | Application Profile |
|---|---|---|
| UHPLC, Agilent 1290 | 2 Units | High-speed separation & ultra-sensitive assay validation |
| HPLC, Agilent 1260 | 4 Units | Routine active ingredient assay & fingerprint profiling |
| HPLC, Shimadzu LC-20AT | 2 Units | Precision standard component analysis |
| ELSD, Shimadzu 2000ES | 2 Units | Detection of non-chromophoric lipids and glycosides |
| Shimadzu GC-2010 | 1 Unit | Volatile organic compound & residual solvent analysis |
| Shimadzu AA-7000 | 1 Unit | Heavy metals (Pb, Cd, As, Hg) atomic absorption profiling |
Control at the source: how UniCare guarantees raw material traceability and sustainable harvesting from our own GAP cultivation bases.
UniCare invests 10% of our annual net profit in research and development. In addition to optimizing and developing the existing natural plant extraction process, we have also established a professional R&D department for the natural fermentation products. By increasing investment in natural fermentation products, we try to break through the traditional processes and disrupt industry development.
UniCare has deep cooperation with Beijing University of Chemical Technology in the field of fermentation, jointly developing and transforming the new raw materials of pharmaceutical, cosmetic, and natural health products into mass-produced products.
In order to control raw materials more efficiently and with higher quality, a raw material procurement system has been established, which extends procurement to every piece of planting land and can trace the raw materials of each batch of products. The storage of raw materials is operated according to the advanced quality management system process, and the content of active ingredients, moisture, ash, heavy metals, pesticide residues and other items of raw materials are strictly controlled.
At the same time, in order to further ensure the high quality of important products, UniCare cooperated with planting farmers to establish ginkgo leaf planting bases, epimedium planting bases, phellodendron planting bases, olive leaf planting bases, etc. Some of these bases are planted strictly in accordance with the GACP management model. In addition, we cooperate with seedling research and development companies to develop high-content seedling cultivation, and cultivate better seedlings through hybridization or gene optimization, so as to continuously reduce unit costs to benefit users.
Ensuring seamless commercial scaling for pharmaceutical companies and supplement brands globally.
Our bulk Biorutin is formulation-ready. It features excellent compatibility parameters with standard hemorrhoidal bases such as hard fat, cocoa butter, and hydrogels for suppository manufacturing, as well as binding agents for compressed oral tablets. We supply specific grades matching European Pharmacopoeia (EP) and United States Pharmacopoeia (USP) standards, guaranteeing low ash limits and highly standardized flavonol glycoside concentrations.
Global entry requires meticulous documentation. UniCare provides comprehensive regulatory dossiers including Allergen Statements, Non-GMO Declares, BSE/TSE Certificates, and DMF (Drug Master Files) documentation. We assist our global clients with local customs compliance, FDA registrations, and food additive notifications in target markets across the EU, North America, and Latin America.
Take a closer look at our physical infrastructure, showing clinical extraction workshops and sterile processing spaces.
Direct technical answers from our senior scientific engineering department to assist your supply chain audit.
Our Biorutin is extracted from premium flower buds of Sophora japonica L. (Japanese pagoda tree) collected at their peak flavonoid concentration. We employ strict raw material inspection before extraction to verify baseline rutin levels exceed 20% in the dried flower buds before processing.
Our GMP factories use food-grade ethanol and purified water as extraction solvents. Organic solvents are completely removed through vacuum low-temperature evaporation and advanced spray-drying systems. We analyze every batch with Shimadzu GC-2010 gas chromatographs to ensure residual solvents are well below USP/EP pharmacopoeia limits.
Yes, we provide customizable micronization. While standard extract powders pass through an 80-mesh screen, we can provide specialized ultra-fine grades (down to D90 < 10 microns) which are optimal for incorporating into topical anti-hemorrhoidal creams and ointments to prevent grit texture and ensure maximum surface contact.
With our 30,000-ton processing capacity, we maintain consistent stock of core bioflavonoid intermediates. Shipping from major Chinese shipping ports (like Shanghai or Qingdao) typically takes 15-20 days to Europe and 18-25 days to North American ports. Air freight options are available for urgent clinical manufacturing requirements.
Premium plant extracts manufactured to strict international GMP pharmacopoeia standards for pharmaceuticals, dietary supplements, and nutraceutical applications.
