Hesperidin, historically classified under the umbrella term Vitamin P, is a prominent flavanone glycoside naturally found in abundance in citrus fruits (primarily orange, lemon, and tangerine peels). Biochemically, it comprises the aglycone hesperetin bound to the disaccharide rutinose. As a critical dietary bioflavonoid, Hesperidin serves as a cornerstone ingredient for modern pharmaceutical and nutraceutical formulations targeting microvascular stability, antioxidant enzyme up-regulation, and cellular defense systems.
The global demand for high-purity Vitamin P Hesperidin has surged dramatically over the past decade. Industry statistics project a compound annual growth rate (CAGR) of over 6.5% for bioflavonoids through 2030. This growth is propelled by its crucial application in venotonic therapeutics (such as the widespread micronized purified flavonoid fraction - MPFF), sports nutrition, cardiovascular formulas, and cosmetic skin-brightening agents. As global consumers pivot toward preventative wellness, wholesale procurement of Hesperidin has transition from a niche pharmaceutical input to a mainstream nutraceutical commodity.
Figure 1: High-efficiency analytical separation and purity determination of bioflavonoids in our primary extraction laboratory.
UniCare is a professional supplier of natural active ingredients. Our products are widely used in various fields such as dietary supplement, food, cosmetics and pharmaceuticals. We focus on product development and quality stability, and insist on growing together with our customers around the world.
UniCare has deep cooperation with several excellent Chinese manufacturers who have complete quality management system certifications, including but not limited to GMP, EUGMP, CEP, ISO9001, ISO22000, and HACCP. Each factory has independent testing capabilities and is equipped with advanced and efficient testing equipment to ensure the high quality and long-term stability of each batch of products.
We work tirelessly to discover and create the new value of herbs, bringing ancient botanical benefits to light through modern extraction techniques.
Continuous innovation and improvement drive our process engineering, enabling us to consistently optimize yields and purity ratios.
With the most advanced technology, we produce the highest quality products, ensuring every batch meets international pharmaceutical standards.
Make the employees happy and give back to the community, establishing sustainable wild-harvesting and processing loops.
UniCare attaches great importance to the hardware conditions of production equipment and operates through one of the largest and most advanced extraction networks in China. The entire production line in UniCare is controlled by a modern, intelligent, automatic control system.
Until now, UniCare has built up two GMP workshops, containing six multi-functional extraction lines, among which there is the only production line for Ginkgo Biloba Extract of acetone process in the whole China. Here are several other production lines including fermentation production lines and Chinese medicine pieces. A total of 30,000 tons of various Chinese medicine plant raw materials can be processed each year.
The facility has passed China-GMP certification, maintaining systematic traceability for pharmaceutical-grade bioflavonoid isolation.
Demonstrated chemical synthesis compliance: The EU-GMP and CEP of Ginkgo Biloba Extract have been certified, reflecting our capability to meet rigorous EU standards.
All extraction production lines adopt modern, intelligent, and automated control systems to minimize human error and ensure batch-to-batch consistency.
We own the most advanced extraction equipment in China, optimizing extraction efficiency, reducing chemical solvent footprint, and protecting active molecules.
Three annular dynamic countercurrent extraction lines (10 tons & 15 tons); two multi-functional extraction lines (32 extraction tanks with 6m³ each); one round dynamic countercurrent extraction line (10 tons).
Equipped with six fermentation tanks (20 tons capacity each) specifically built for the production of enzyme-modified flavonoid products like Hesperetin.
United New Life has established a leading and complete quality control system, strictly controlling the high quality of products in accordance with quality system regulations.
With advanced testing instruments, we perform strict control of product quality to provide every customer with premium products. Detectable items include:
| Instrument Model | Quantity | Core Application |
|---|---|---|
| UHPLC, Agilent 1290 | 2 Sets | Ultra-high resolution assay of flavonoids & related glycosides |
| HPLC, Agilent 1260 | 4 Sets | Routine assay and profile analysis of botanical active ingredients |
| HPLC, Shimadzu LC-20AT | 2 Sets | Quantitative analysis of markers in herb products |
| HPLC, Dionex UltiMate 3000 (Diane CU3000) | 2 Sets | Precise trace-component identification |
| ELSD, Shimadzu 2000ES | 2 Sets | Evaporative light scattering detection for non-UV absorbing molecules |
| Shimadzu GC-2010 | 1 Set | Volatile organic compound analysis & organic solvent residue testing |
| Shimadzu AA-7000 | 1 Set | Atomic Absorption Spectroscopy for heavy metal screening |
Figure 2: Our CNAS-qualified laboratory testing site ensuring chemical stability.
| Quality Control Category | Testing and Verification Protocols |
|---|---|
| Active Ingredient Analysis | Assay determination, chemical profile fingerprinting, and TLC/HPLC identification. |
| Hazardous Substance Analysis | Heavy metals profiling (lead, cadmium, mercury, arsenic), pesticide residues GC-MS-MS screening, and organic solvent residues verification. |
| Microbe Analysis | Total viable aerobic counts, Escherichia coli screening, Salmonella detection, yeast and mould counts, and customized specific pathogen test. |
| Raw Material Control | Control of origin, non-GMO verification, identification of allergenic substances, and testing of raw materials for pesticide load prior to entering production. |
| Laws & Regulations Confirmation | Continuous monitoring of regulatory developments across the EU, USA, China, and APAC to ensure compliance of chemical limits. |
| Stability Test | Accelerated and long-term stability testing to establish and guarantee shelf life under varying climatic zones. |
UniCare invests 10% of our annual net profit in research and development. In addition to optimizing and developing the existing natural plant extraction process, we have established a professional R&D department for natural fermentation products. By increasing investment in natural fermentation products, we try to break through the traditional processes and disrupt industry development.
UniCare has deep cooperation with Beijing University of Chemical Technology in the field of fermentation, jointly developing and transforming the new raw materials of pharmaceutical, cosmetic, and natural health products into mass-produced products.
In order to control raw materials more efficiently and with higher quality, a raw material procurement system has been established, which extends procurement to every piece of planting land and can trace the raw materials of each batch of products.
To ensure the high quality of important products, UniCare cooperated with planting farmers to establish ginkgo leaf planting bases, epimedium planting bases, phellodendron planting bases, olive leaf planting bases, etc. Some of these bases are planted strictly in accordance with the GACP management model. In addition, we cooperate with seedling R&D companies to cultivate better seedlings through hybridization or gene optimization, minimizing cost-per-unit while upgrading yield potency.
Used as a critical API component for venotonic preparations, typically formulated at a 10% Hesperidin to 90% Diosmin ratio (MPFF). It helps alleviate Chronic Venous Insufficiency (CVI) and microvascular bleeding.
Commonly integrated with Vitamin C to enhance microvascular capillary walls, protect blood vessel structure, and act as a synergist for immune defence formulations.
Applied in under-eye creams to tackle dark circles by boosting microcirculation under thin skin layers, while offering powerful antioxidant defense against UV-induced free radicals.
