As longevity research and metabolic sciences advance, Cotinus Coggygria Plant Extract (P.E.)—predominantly valued as the premier natural source of the senolytic flavonoid Fisetin—has evolved from a traditional botanical component to an essential raw material for global nutraceutical, cosmetic, and pharmaceutical industries. Cotinus coggygria, commonly known as the smoke tree or Venetian sumac, belongs to the Anacardiaceae family. Its wood and leaves contain high concentrations of bioactive polyphenols and flavonoids, notably fisetin, sulfuretin, and gallic acid.
At UniCare, we operate as a leading bridge between raw agricultural potential and high-purity industrial supply. Our manufacturing methodologies are tailored to optimize the bio-accessibility of Cotinus Coggygria extracts. By integrating advanced molecular extraction pathways, we guarantee consistent concentrations of active Fisetin, meeting the stringent regulatory guidelines of global markets including the United States, Europe, and the Asia-Pacific region.
China accounts for the majority of the global market supply of Cotinus Coggygria P.E. This dominance is not only due to rich natural habitats but also to a sophisticated, integrated extraction ecosystem.
The mountainous areas of Shaanxi, Henan, and Sichuan provinces provide ideal soil and climatic conditions for Cotinus coggygria. These regions act as stable sourcing corridors, allowing factories to secure fresh wood and leaves with high initial flavonoid densities.
Modern Chinese facilities, including UniCare's partner sites, feature automated dynamic countercurrent extraction lines. This technology maximizes yield while maintaining precise temperature control, preventing the thermal degradation of delicate flavonoids.
Processing tens of thousands of tons of botanical inputs annually allows us to offer competitive pricing without compromising quality. Advanced crystallization systems enable high throughput of premium Fisetin powder (98% standard grade).
UniCare is a professional supplier of natural active ingredients. Our products are widely used in various fields such as dietary supplement, food, cosmetics and pharmaceuticals. We focus on product development and quality stability, and insist on growing together with our customers around the world.
UniCare has deep cooperation with several excellent Chinese manufacturers who have complete quality management system certifications, including but not limited to GMP, EUGMP, CEP, ISO9001, ISO22000, and HACCP. Each factory has independent testing capabilities and is equipped with advanced and efficient testing equipment to ensure the high quality and long-term stability of each batch of products.
Unlocking the hidden potential of herbal matrices via molecular extraction and engineering.
Constantly refining our processes to maximize yields, bio-efficacy, and chemical stability.
Deploying state-of-the-art facilities to produce top-tier ingredients compliant with EU-GMP.
Creating a supportive environment for our employees and returning value to local farming families.
UniCare prioritizes high-specification hardware. We operate one of the largest and most advanced botanical extraction factories in China. The entire production line is controlled by a modern, intelligent, automated control system.
Currently, UniCare operates two GMP workshops containing six multi-functional extraction lines, including the only production line for Ginkgo Biloba Extract using the acetone process in all of China. Additional lines support fermentation processes and Chinese medicine pieces, allowing us to process up to 30,000 tons of natural plant raw materials annually.
A look into our GMP production spaces, state-of-the-art crystallization systems, and sterile handling zones.
United New Life has established a leading and complete quality control system, and strictly controls the high quality of products in accordance with the quality system. Detectable items include signature component verification, solvent residues, pesticide residues, and heavy metals.
With advanced testing instruments, we monitor batch parameters to provide consistent product profiles. Key measurements include:
Our analytical lab is equipped with advanced instrumentation to verify batch stability:
| Instrument Type | Model / Brand | Quantity |
|---|---|---|
| UHPLC (Ultra High Performance Liquid Chromatograph) | Agilent 1290 | 2 Sets |
| HPLC (High Performance Liquid Chromatograph) | Agilent 1260 | 4 Sets |
| HPLC | Shimadzu LC-20AT | 2 Sets |
| HPLC | Dionex Ultimate 3000 | 2 Sets |
| ELSD (Evaporative Light Scattering Detector) | Shimadzu 2000ES | 2 Sets |
| Gas Chromatograph (GC) | Shimadzu GC-2010 | 1 Set |
| Atomic Absorption Spectroscopy (AAS) | Shimadzu AA-7000 | 1 Set |
| Quality Assurance Phase | Analytical Protocol & Scope |
|---|---|
| Active Ingredient Analysis | Assay testing, peak area calculation, identification using reference standards. |
| Hazardous Substance Analysis | Limits validation for heavy metals, organophosphorus pesticides, and volatile residues. |
| Microbe Analysis | Total aerobic microbial count, yeast/mold count, and negative screening for E. coli/Salmonella. |
| Raw Material Control | Species identification, geographical authenticity, GMO screening, and residue monitoring. |
| Regulatory Alignment | Verification of compliance with pharmacopeias (USP, EP, ChP) across primary export markets. |
| Stability Studies | Accelerated and long-term testing to establish shelf life under various climatic conditions. |
UniCare reinvests 10% of our annual net profit into research and development. In addition to optimizing traditional plant extraction processes, we have established a dedicated team for bio-fermentation. This work aims to develop alternative pathways to traditional botanical extraction.
We maintain an ongoing partnership with the Beijing University of Chemical Technology in the field of fermentation. This collaboration supports the development of new raw materials for the pharmaceutical, cosmetic, and health supplement industries, facilitating their transition to industrial-scale production.
To manage materials effectively, we maintain a raw material procurement system that traces each batch to its cultivation site. Incoming materials are checked for active compound levels, moisture, ash, heavy metals, and pesticide residues.
To ensure consistent quality, UniCare partners with local growers to manage dedicated planting bases for ginkgo leaf, epimedium, phellodendron, and olive leaf. Select bases are managed according to the GACP (Good Agricultural and Collection Practices) model. We also work with plant breeding companies to develop cultivars with higher active compound yields.
Fisetin derived from Cotinus Coggygria is widely used across the nutraceutical, functional food, and cosmetic sectors due to its biochemical activities.
Fisetin has been studied for its senolytic activity—the ability to selectively clear senescent cells. This has made it a popular ingredient in healthy aging and longevity product formulations globally.
Research suggests that Fisetin supports long-term potentiation and helps protect brain cells from oxidative stress. It is increasingly utilized in specialty nootropic blends for cognitive support.
Its antioxidant and anti-inflammatory properties make Cotinus Coggygria P.E. a functional ingredient in topical formulations designed to target signs of aging and environmental skin damage.
Global buyers often face challenges regarding residual solvents, fluctuating purity levels, and batch-to-batch variation. UniCare addresses these issues through systematic control:
We use green extraction processes employing ethanol and water, avoiding harsh chlorinated solvents. Gas chromatography ensures all final products meet strict international standards for organic residual solvents.
Our extraction protocols are standardized to minimize variation in active polyphenol levels. Every batch is supplied with HPLC validation profiles, verifying chemical composition before shipment.
Common inquiries from procurement teams, quality control managers, and formulation experts.
