Explore our foundational active ingredients sourced and standardized for international formulations.
Why global pharmaceutical and dietary supplement brands route their CoQ10 supply chains through China's advanced bio-fermentation hubs.
Coenzyme Q10 (Ubiquinone), a critical fat-soluble quinone compound necessary for cellular energy production (ATP synthesis), is manufactured at scale in China utilizing state-of-the-art bacterial fermentation. Unlike traditional semi-synthetic processes which rely on solanesol raw materials, modern Chinese factories utilize optimized strains of Rhodobacter sphaeroides or Sphingomonas species to ferment glucose and beet molasses into pure, trans-isomer CoQ10.
This biological pathway yields an ingredient with 100% bio-identity to the Coenzyme Q10 produced naturally within human cells. Global procurement directors benefit from unmatched scale economies, robust yield stability, and a dramatically lower carbon footprint, satisfying sustainability metrics alongside strict biochemical purity standards.
Our domestic manufacturing infrastructure handles over 60% of the world's bulk Coenzyme Q10 demand, delivering compliant USP, EP, and JP grades verified by Third-Party US and European laboratories.
Leveraging specialized crystallization processes, our bulk CoQ10 features zero trace cis-isomers. This maximizes bioactivity, reduces waste during formulation, and strictly complies with the United States Pharmacopeia (USP).
We provide standard crystalline powders, Cold Water Dispersible (CWD) microencapsulated formulations for functional beverages, and oil-suspended versions tailored for softgel applications.
By producing raw fermentation media and holding multi-year raw material contracts, we isolate global buyers from localized market price spikes and supply disruptions.
A trusted partner in the development, quality standardization, and global distribution of active botanical and biochemical ingredients.
UniCare is a professional supplier of natural active ingredients. Our products are widely used in various fields such as dietary supplement, food, cosmetics and pharmaceuticals. We focus on product development and quality stability, and insist on growing together with our customers around the world.
UniCare has deep cooperation with several excellent Chinese manufacturers who have complete quality management system certifications, including but not limited to GMP, EUGMP, CEP, ISO9001, ISO22000, and HACCP. Each factory has independent testing capabilities and is equipped with advanced and efficient testing equipment to ensure the high quality and long-term stability of each batch of products.
Guiding our industrial R&D and manufacturer partnerships toward sustainable global health solutions.
UniCare attaches great importance to the hardware conditions of production equipment and has the largest and most advanced extraction factory in China. The entire production line in UniCare is controlled by a modern, intelligent, automatic control system.
Until now, UniCare has built up two GMP workshops, containing six multi-functional extraction lines, among which there is the only production line for Ginkgo Biloba Extract of acetone process in the whole China. Here are several other production lines including fermentation production lines and Chinese medicine pieces. A total of 30,000 tons of various Chinese medicine plant raw materials can be processed each year.
Our manufacturing partners fully comply with domestic GMP specifications to guarantee batch consistency.
The EU-GMP and CEP certifications of Ginkgo Biloba Extract stand as a benchmark of our high pharmaceutical-grade compliance.
All extraction and crystallization lines adopt modern, integrated, and fully automated monitoring systems.
Equipped with the most sophisticated extraction systems available in mainland China.
Robust supply chain security supporting major global health and nutritional brands.
Three dynamic countercurrent extraction lines (10T & 15T); two multi-functional lines (32 tanks, 6m³ each); one dynamic unit (10T).
Host to the only acetone process extraction line for Ginkgo Biloba Extract in China meeting EU GMP standards.
Six 20-ton fermentation tanks optimized for producing customized enzyme-modified products.
In-depth analytical comparison for procurement officers looking to optimize purity, bio-performance, and formulation costs.
When selecting a wholesale Coenzyme Q10 partner, analytical precision is paramount. Bulk buyers must balance the physical parameters of the powder (crystallinity, flowability, static charge, bulk density) with strict chemical metrics (assay limits of 98.0%–101.0%, organic solvents residue, heavy metals profile). The selection of the microbial strain determines the absence of chemical impurities that are typical of lower-tier synthesis routes.
Additionally, Coenzyme Q10 exists in two key biological states: **Ubiquinone** (the oxidized form, highly stable, widely used in classic dietary supplement formulations) and **Ubiquinol** (the reduced form, highly bioavailable but sensitive to oxygen exposure). Leading Chinese factories utilize nitrogen-flushed crystallization and oxygen-barrier packaging technologies to deliver bulk Ubiquinol with proven stability over its full 36-month shelf life.
For cosmetic formulations, regular crystalline CoQ10 is challenging to integrate due to its large crystal structure and hydrophobic nature. Our partners solve this by providing nano-emulsified liquid Coenzyme Q10, which easily disperses in water-based cosmetic serums, maximizing cellular energy reactivation within dermal tissues. This technical customization is what differentiates a standard factory from an advanced technology partner.
| CoQ10 Formulation Type | Active Concentration | Physical Form | Primary Industrial Application | Bioavailability Index |
|---|---|---|---|---|
| Standard Ubiquinone Crystalline | 98% - 101% | Yellow Crystalline Powder | Softgels, Hard-shell Capsules, Tablets | Baseline (Standard Absorption) |
| Cold Water Dispersible (CWD) Powder | 10%, 20%, 40% | Light Yellow Free-flowing Powder | Functional Beverages, Dry Mixes, Effervescents | 2x Enhanced Bioavailability |
| Oil Suspension | 20%, 30% | Viscous Yellow Liquid / Paste | Liquid Capsules, Gummy Centers, Softgels | 1.5x Enhanced Bioavailability |
| Nano-Emulsified Liquid (Cosmetic) | 1%, 5%, 10% | Clear to Semi-translucent Liquid | Anti-aging Serums, Creams, Lotions | Maximum Dermal Penetration |
| Standard Ubiquinol (Reduced Form) | 96% - 102% | White to Pale Yellow Powder | Premium Cardiovascular & Anti-fatigue Supplements | 3x to 4x Superior Bioavailability |
Our centralized testing protocols guarantee absolute compliance with international food and drug safety parameters.
United New Life (UniCare) has established a leading and complete quality control system, and strictly controls the high quality of products in accordance with the quality system. With advanced testing instruments, strict control of product quality, to provide every customer with high quality products.
Detectable items are: Signature component detection (HPLC or UV), solvent residues GC, pesticide residues (organochlorine detection) GC-MS-MS, heavy metals (lead, arsenic, mercury, cadmium, copper) ICP-MS microscopic identification, moisture, dry weight loss, ash, microbial limits, thin layer identification, weighing, conductivity, PH, sulfur dioxide residue, routine detection, etc.
Important testing instruments are: Two UHPLC Agilent 1290 ultra-high performance liquid chromatographs, four HPLC Agilent 1260 high performance liquid chromatography sets, there are two HPLC Shimadzu LC-20AT high performance liquid chromatograph, two HPLC Diane CU3000, two Shimadzu evaporative light scattering detector 2000ES, one Shimadzu GC2010 gas chromatograph, and one Shimadzu AA-7000 atomic absorption system.
| Quality Control Area | Analytical Parameters |
|---|---|
| Active Ingredient Analysis | Assay, chemical identification, isomer profiling |
| Hazardous Substance Analysis | Heavy metals (ICP-MS), pesticide residue (GC-MS-MS), solvent residue (GC-headspace) |
| Microbial Analysis | Total plate count, Escherichia coli, Yeast & mould, Salmonella, specific pathogens |
| Raw Material Control | Pesticide screening, allergen tracking, GMO verification, geographical origin vetting |
| Regulatory Validation | Cross-border regulatory alignment (FDA, EFSA, CFDA, PMDA rules) |
| Stability Studies | Real-time and accelerated stability tests under variable humidity/temperature |
| Physical Constants | pH value, moisture, ash, optical rotation, bulk/tapped density, mesh size |
Central Laboratory: CNAS Qualified Facility. Primary instrumentation inventory includes: UHPLC Agilent 1290 (x2), HPLC Agilent (x4), HPLC Shimadzu LC-20AT (x2), ELSD Shimadzu 2000ES (x2), Shimadzu GC-2010 (x1), Shimadzu AA-700 (x1).
Bridging cutting-edge biotechnology with sustainable agricultural supply lines to maintain cost leadership.
UniCare invests 10% of our annual net profit in research and development. In addition to optimizing and developing the existing natural plant extraction process, we have also established a professional R&D department for natural fermentation products. By increasing investment in natural fermentation products, we try to break through traditional processes and disrupt industry development.
UniCare has deep cooperation with Beijing University of Chemical Technology (BUCT) in the field of fermentation, jointly developing and transforming the new raw materials of pharmaceutical, cosmetic, and natural health products into mass-produced products.
In order to control raw materials more efficiently and with higher quality, a raw material procurement system has been established, which extends procurement to every piece of planting land and can trace the raw materials of each batch of products. Storage is operated according to the advanced quality management system process. Active ingredients, moisture, ash, heavy metals, and pesticide residues are strictly controlled.
At the same time, UniCare cooperated with planting farmers to establish ginkgo leaf planting bases, epimedium planting bases, phellodendron planting bases, olive leaf planting bases, etc. Some bases are managed strictly under the GACP model. We also cooperate with seedling research and development companies to develop high-content seedling cultivation via hybridization or gene optimization to continuously reduce unit costs for users.
Clear, authoritative answers to the most critical technical questions raised by quality assurance and supply chain directors.
Our manufacturing partners employ a proprietary multi-stage crystallization process using food-grade organic solvents. By precisely controlling cooling rates and seeding temperatures, we isolate the all-trans configuration, yielding 100% trans-isomer product. The absence of cis-isomers is verified via high-performance liquid chromatography (HPLC) in our CNAS-certified laboratory.
Standard CoQ10 has a melting point of approximately 48–52°C and is insoluble in water. Our CWD formulation utilizes microencapsulation (specifically starch or dextrin matrices), reducing the particle size to the micellar scale. This enables rapid dispersion in cold liquids, preventing precipitation and significantly improving intestinal bioavailability in functional beverage applications.
Our partner production facilities are audited and certified under China GMP, EU-GMP, ISO 9001, ISO 22000, HACCP, and hold CEP validation for select plant extracts. Furthermore, our processes align with FSMA requirements, allowing smooth custom clearance and integration into US and European dietary supplement production lines.
Because Ubiquinol is highly sensitive to atmospheric oxygen, it is packaged under nitrogen flushing in triple-layer, light-blocking vacuum aluminum foil bags, which are then placed in fiber drums. We recommend storing the material below 25°C in sealed conditions to preserve the 3-year warranty shelf life.
Our standard MOQ for bulk Coenzyme Q10 is 25 kg (one standard drum). We maintain strategic inventory reserves in domestic customs warehouses, allowing domestic port delivery within 5–7 working days, and global air freight delivery within 10–14 days depending on destination logistics.
Browse the remainder of our advanced extraction and fermentation portfolio available for global contract manufacturing.
